Evidence map›Paper›PMID 35588703›Full record

ArticleDevelopmental neuroscience2022

Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia.

Jana Krystofova Mike, Katherine Y Wu, Yasmine White, Praneeti Pathipati, Blaise Ndjamen, Rachel S Hutchings, Courtney Losser, Christian Vento, Kimberly Arellano, Oona Vanhatalo and 14 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 2 countries.

Jana Krystofova MikeDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Katherine Y WuDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Yasmine WhiteDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Praneeti PathipatiDepartment of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Blaise NdjamenHistology and Microscopy Core, Gladstone Institutes University of California San Francisco, San Francisco, California, USA.
Rachel S HutchingsDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Courtney LosserDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Christian VentoDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Kimberly ArellanoDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Oona VanhataloDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Samuel OstrinDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Christine WindsorDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Janica HaDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Ziad AlhassenDepartment of Pediatrics, University of California Davis, Davis, California, USA.
Brian D GoudyDepartment of Pediatrics, University of California Davis, Davis, California, USA.
Payam ValiDepartment of Pediatrics, University of California Davis, Davis, California, USA.
Satyan LakshminrusimhaDepartment of Pediatrics, University of California Davis, Davis, California, USA.
Jogarao V S GobburuSchool of Pharmacy, University of Maryland, Baltimore, Maryland, USA.
Janel Long-BoyleInitiative for Pediatric Drug and Device Development, San Francisco, California, USA.
Peggy ChenDepartment of Pediatrics, University of California Davis, Davis, California, USA.
Yvonne W WuDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Jeffrey R FinemanDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Donna M FerrieroDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Emin MaltepeDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
University of California, San Francisco · USUniversity of California, Davis · USGladstone Institutes · USUniversity of Maryland, Baltimore · US

Funding

CLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9M
Precision Therapy for Neonatal Brain InjuryR35NS097299 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIERO, DONNA M. · 2017 to 2024
$6.3M
Optimal Oxygenation in Neonatal Lung InjuryR01HD072929 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Satyanarayana Lakshminrusimha · 2012 to 2026
$5.4M
Integrating Environmental Cues at the Maternal-Fetal Vascular InterfaceR01HD072455 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALTEPE, EMIN · 2012 to 2023
$4.3M
The Child Health Research Career Development Program at UCSFK12HD105250 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raphael Hirsch · 2021 to 2026
$2.5M
Improving Efficacy of Chest Compressions in the Perinatal Asphyxiated Cardiac Arrest Lamb ModelR03HD096299 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VALI, PAYAM · 2018 to 2019
$157k
NICHD NIH HHS K12 HD105250NICHD NIH HHS R01 HD072455NICHD NIH HHS R01 HD072929NICHD NIH HHS R03 HD096299NIGMS NIH HHS T32 GM007546NINDS NIH HHS R35 NS097299
6 · The paper itself

Abstract

Hypoxic-ischemic encephalopathy (HIE) is the leading cause of neonatal morbidity and mortality worldwide. Approximately 1 million infants born with HIE each year survive with cerebral palsy and/or serious cognitive disabilities. While infants born with mild and severe HIE frequently result in predictable outcomes, infants born with moderate HIE exhibit variable outcomes that are highly unpredictable. Here, we describe an umbilical cord occlusion (UCO) model of moderate HIE with a 6-day follow-up. Near-term lambs (n = 27) were resuscitated after the induction of 5 min of asystole. Following recovery, lambs were assessed to define neurodevelopmental outcomes. At the end of this period, lambs were euthanized, and brains were harvested for histological analysis. Compared with prior models that typically follow lambs for 3 days, the observation of neurobehavioral outcomes for 6 days enabled identification of animals that recover significant neurological function. Approximately 35% of lambs exhibited severe motor deficits throughout the entirety of the 6-day course and, in the most severely affected lambs, developed spastic diparesis similar to that observed in infants who survive severe neonatal HIE (severe, UCOs). Importantly, and similar to outcomes in human neonates, while initially developing significant acidosis and encephalopathy, the remainder of the lambs in this model recovered normal motor activity and exhibited normal neurodevelopmental outcomes by 6 days of life (improved, UCOi). The UCOs group exhibited gliosis and inflammation in both white and gray matters, oligodendrocyte loss, neuronal loss, and cellular death in the hippocampus and cingulate cortex. While the UCOi group exhibited more cellular death and gliosis in the parasagittal cortex, they demonstrated more preserved white matter markers, along with reduced markers of inflammation and lower cellular death and neuronal loss in Ca3 of the hippocampus compared with UCOs lambs. Our large animal model of moderate HIE with prolonged follow-up will help further define pathophysiologic drivers of brain injury while enabling identification of predictive biomarkers that correlate with disease outcomes and ultimately help support development of therapeutic approaches to this challenging clinical scenario.

Indexed as

GliosisHypoxia-Ischemia, BrainAnimalsBiomarkersBrainFemaleHumansInfantInflammationIschemiaPregnancySheepBiomarkersBrain hypoxia-ischemiaNeonatesNeurodevelopmental outcomesOvine model

Identifiers

PMID35588703
PMCPMC9474697
OpenAlexW4280501861

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.