Evidence map›Paper›PMID 35588573›Full record

ArticleThe Journal of surgical research2022

The Association Between Metabolic Derangement and Wound Complications in Elective Plastic Surgery.

Amanda R Sergesketter, Yisong Geng, Ronnie L Shammas, Gerald V Denis, Robin Bachelder, Scott T Hollenbeck

Open access · greenAbstract read
In one paragraph

Article in The Journal of surgical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Prehabilitation for Pressure Ulcer Surgery: A Practical and Evidence-based Guide.Plastic and reconstructive surgery. Global open · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amanda R SergesketterDivision of Plastic, Oral, and Maxillofacial Surgery, Duke University, Durham, North Carolina.
Yisong GengCalc LLC, Wilton, Connecticut.
Ronnie L ShammasDivision of Plastic, Oral, and Maxillofacial Surgery, Duke University, Durham, North Carolina.
Gerald V DenisSection of Hematology/Oncology, Boston University School of Medicine, Boston, Massachusetts.
Robin BachelderDivision of Plastic, Oral, and Maxillofacial Surgery, Duke University, Durham, North Carolina.
Scott T HollenbeckDivision of Plastic, Oral, and Maxillofacial Surgery, Duke University, Durham, North Carolina. Electronic address: scott.hollenbeck@duke.edu.
Duke University · USBoston University · US

Funding

Mechanisms of BET bromodomain metabolic reprogramming in triple negative breast cancerR01CA222170 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DENIS, GERALD V · 2018 to 2022
$3.1M
Multiscale analysis of metabolic inflammation as a driver of breast cancerU01CA243004 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DENIS, GERALD V, EMILI, ANDREW · 2020 to 2024
$2.8M
NCI NIH HHS R01 CA222170NCI NIH HHS U01 CA243004
6 · The paper itself

Abstract

introductionThe incidence of metabolically unhealthy obesity is rising nationally. In this study, we compare wound and overall complications between metabolically unhealthy obese and healthy patients undergoing elective plastic surgery and model how operative time influences a complication risk.

methodsPatients undergoing elective breast and body plastic surgery procedures in the 2009-2019 National Surgical Quality Improvement Program (NSQIP) dataset were identified. Complications were compared between metabolically unhealthy obese (body mass index [BMI] > 30 with diabetes and/or hypertension) versus metabolically healthy obese patients (BMI > 30 without diabetes or hypertension). Logistic regression was used to model the probability of wound complications across operative times stratified by metabolic status.

resultsOf 139,352 patients, 13.4% (n = 18,663) had metabolically unhealthy obesity and 23.8% (n = 33,135) had metabolically healthy obesity. Compared to metabolically healthy patients, metabolically unhealthy patients had higher incidence of wound complications (6.9% versus 5.6%; P < 0.001) and adverse events (12.4% versus 9.6%; P < 0.001), in addition to higher 30-d readmission, returns to the operating room, and length of stay (all P < 0.001). After adjustment, BMI (Odds ratio [OR] 7.86), hypertension (OR 1.15), and diabetes (OR 1.25) were independent risk factors for wound complications (all P < 0.001). Among metabolically unhealthy patients, the operative time was log-linear with a wound complication risk (OR 1.21; P < 0.001).

conclusionsDiabetes and hypertension are additive risk factors with obesity for wound complications in elective plastic surgery. Among patients with metabolically unhealthy obesity, a risk of wound complications increases logarithmically with operative time. This distinction with regard to metabolic state might explain the unclear impact of obesity on surgical outcomes within existing surgical literature.

Indexed as

HypertensionObesity, Metabolically BenignSurgery, PlasticBody Mass IndexHumansObesityRisk FactorsDiabetesMetabolic syndromeObesityOperative timePlastic surgeryWound healing

Identifiers

PMID35588573
PMCPMC9329200
OpenAlexW4280491959

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.