Evidence map›Paper›PMID 35588530›Full record

ArticleJournal of the American Chemical Society2022

Sea Urchin Polyketide Synthase SpPks1 Produces the Naphthalene Precursor to Echinoderm Pigments.

Feng Li, Zhenjian Lin, Joshua P Torres, Eric A Hill, Dehai Li, Craig A Townsend, Eric W Schmidt

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. More than a colour; how pigment influences colourblind microbes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Review
  8. Article
  9. Animal FAS-like polyketide synthases produce diverse polypropionates.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Review
  11. CRISPR/Cas9 knockin methodology for the sea urchin embryo.Molecular reproduction and development · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Feng LiKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China.
Zhenjian LinDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
Joshua P TorresDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0003-2601-0699
Eric A HillDepartment of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, United States.
Dehai LiKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China.ORCID 0000-0002-7191-2002
Craig A TownsendDepartment of Chemistry, The Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0003-2795-7585
Eric W SchmidtDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0001-5839-694X
University of Utah · USJohns Hopkins University · USOcean University of China · CN

Funding

Symbiosis and Chemical Diversity GenerationR35GM122521 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2017 to 2021
$2.9M
NIGMS NIH HHS R35 GM122521
6 · The paper itself

Abstract

Nearly every animal species on Earth contains a unique polyketide synthase (PKS) encoded in its genome, yet no animal-clade PKS has been biochemically characterized, and even the chemical products of these ubiquitous enzymes are known in only a few cases. The earliest animal genome-encoded PKS gene to be identified was

Indexed as

PolyketidesPolyketide SynthasesAnimalsNaphthalenesPhylogenySea UrchinsNaphthalenesPolyketidesPolyketide Synthases

Identifiers

PMID35588530
PMCPMC9526445
OpenAlexW4280603417

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.