ArticleBrain and behavior2022
Prognostic value of the systemic inflammation response index in patients with acute ischemic stroke.
Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Systemic inflammation response index as a clinical outcome evaluating tool and prognostic indicator for hospitalized stroke patients: a systematic review and meta-analysis.European journal of medical research · 2023Pooled it
- Admission Systemic Immune-Inflammation Index Is Associated with Cognitive Performance and Handgrip Strength Three Months After First-Ever Acute Ischaemic Stroke: A Prospective Cohort Study.Brain sciences · 2026Article
- The Prognostic Role of C-Reactive Protein-Triglyceride Glucose Index in Predicting Unfavorable Outcomes in Acute Ischemic Stroke: A Large-Scale Cohort Study.Brain and behavior · 2026Article
- Preoperative Systemic Inflammatory Response Index (SIRI) as a predictor of early surgical site infection following instrumented lumbar spine surgery.International orthopaedics · 2026Article
- Development and validation of a predictive model for acute respiratory distress syndrome in moderate-to-late preterm infants: a multicenter retrospective study.European journal of pediatrics · 2026Article
- Prognostic Value of Inflammatory Hematological Indices for In-Hospital Mortality After Stroke.Medicina (Kaunas, Lithuania) · 2026Article
- Immunotherapies for Ischemic Stroke Patients: Current Status and Future Directions.Medical sciences (Basel, Switzerland) · 2026Review
- Association of Complete Blood Count-Derived Inflammatory Markers with Trouble Sleeping: Evidence from Population Data and Experimental Sleep Deprivation.Nature and science of sleep · 2026Article
- The association between inflammatory indices and acute pancreatitis severity: a retrospective cohort study.Frontiers in surgery · 2026Article
- Admission systemic inflammatory indices and 6-month functional outcome after endovascular thrombectomy for acute ischemic stroke: an exploratory single-center cohort study.Frontiers in neurology · 2026Article
- A threshold effect of Apolipoprotein A1 levels on systemic inflammatory response index in individuals with osteoporotic fractures: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Clinical value of SPP1 overexpression in patients with papillary thyroid carcinoma.Translational cancer research · 2025Article
- Variations in haematological and inflammatory biomarkers and their association with Plasmodium falciparum malaria: a cross-sectional comparative study at a clinic in Ghana.Malaria journal · 2025Article
- The predictive role of composite inflammatory ratio parameters in the conscious awareness recovery after severe acute ischemic stroke: a retrospective cohort study.BMC neurology · 2025Article
- Correlation between systemic inflammatory response index and post-stroke epilepsy based on multiple logistic regression analysis.Frontiers in neurology · 2025Article
- Association between the systemic inflammatory response index and acute ischemic stroke in young people.Frontiers in neurology · 2025Article
- Prognostic Value of SIRI in Sepsis: A Retrospective Study and Machine Learning-Based Model Development.Journal of inflammation research · 2025Article
- Association between systemic inflammatory indicators on admission and mortality in critically ill patients with diabetic kidney disease based on the MIMIC-IV database: a cohort study.Frontiers in endocrinology · 2025Article
- Predictive Value of Inflammation Markers for Frailty in Older Patients with CVD.Clinical interventions in aging · 2025Article
- Association of systemic inflammatory response index and stroke: a cross-sectional study of NHANES, 2005-2018.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesInflammation plays an essential role in acute ischemic stroke (AIS). Recent studies have recognized the systemic inflammation response index (SIRI) as a useful index to indicate inflammation status and predict the prognosis of multiple diseases. However, the relationship between SIRI and AIS prognosis is unclear. Our study is aimed to investigate the association between SIRI and the prognosis of AIS.
methodsOur study prospectively recruited 287 consecutive patients with first-ever stroke within 72 h after stroke. Demographic and clinical information was collected at baseline. The functional prognosis was assessed 3 months after AIS using the modified Rankin Scale (mRS). A poor outcome was defined as mRS > 2. SIRI was calculated as neutrophil × monocyte/lymphocyte count. Univariate and multivariate analyses were introduced to identify the association between SIRI and AIS prognosis. Receiver operating characteristic curve and reclassification analyses were used to evaluate the predictive value of SIRI for AIS prognosis.
resultsThe patients with poor prognosis account for 27.5% of all participants. After fully adjusting for all covariates, each standard deviation increment of SIRI caused 58.9% additional risk for poor prognosis after AIS. When dividing SIRI into quartiles, the fourth quartile had a 6.152 times risk than the first quartile. Moreover, after adding SIRI into established clinical risk factors, AUC showed a significant improvement (0.829 vs. 0.790, p for comparison = .016). Consistently, category-free net reclassification index (NRI, 0.761, 95% CI: 0.517-1.004, p < .001) and integrated discrimination index (IDI, 0.093, 95% CI: 0.0512-0.134, p < .001) confirmed the improvement by SIRI to predict poor prognosis of AIS,
conclusionSIRI is an independent prognostic indicator for AIS. Elevated SIRI is associated with poor functional outcome of AIS. Our findings suggest the usefulness of SIRI to refine the risk stratification of unfavorable prognosis of AIS.
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