Evidence map›Paper›PMID 35588331›Full record

ArticleInternational journal of colorectal disease2022

Identification of high-risk stage I colon and rectal cancer patients: a retrospective analysis of a large Japanese cohort.

Yudai Fukui, Koya Hida, Nobuaki Hoshino, Daisuke Nishizaki, Ryosuke Okamura, Shinichi Yamauchi, Kenichi Sugihara, Yoshiharu Sakai, Japanese Study Group for Postoperative Follow-up of Colorectal Cancer

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Article in International journal of colorectal disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yudai FukuiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Koya HidaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan. hidakoya@kuhp.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0001-7210-7075
Nobuaki HoshinoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Daisuke NishizakiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Ryosuke OkamuraDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Shinichi YamauchiDepartment of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Kenichi SugiharaTokyo Medical and Dental University, Tokyo, Japan.
Yoshiharu SakaiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
Japanese Study Group for Postoperative Follow-up of Colorectal Cancer
Kyoto University · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeData regarding risk factors for recurrence in stage I colorectal cancer patients are limited. The aim of this study was to clarify the existence of a high-recurrence-risk population among stage I colorectal cancer patients.

methodsThis analysis included 7,539 stage I colorectal cancer patients treated between 1997 and 2012 at 24 leading hospitals in Japan. Risk factors for time to recurrence were evaluated using a Cox proportional hazards model, and a high-risk group for recurrence was identified. Prognostic outcomes of high-risk stage I colorectal cancer patients were compared with those of low-risk stage I and stage II patients.

resultsMultivariable analyses identified left-sided location (hazard ratio [HR]: 1.65, 95% confidence interval [CI]: 1.09-2.58), T2 tumors (HR: 1.80, 95% CI: 1.21-2.66), and lymphatic invasion (HR: 1.55, 95% CI: 1.05-2.28) as risk factors for recurrence in stage I colon cancer, and patients with these three risk factors were classified as high risk. For stage I rectal cancer, patients with poor differentiation (HR: 2.86, 95% CI: 1.21-5.69), T2 tumors (HR: 1.53, 95% CI: 1.07-2.23), and venous invasion (HR: 1.51, 95% CI: 1.08-2.13) were identified as high risk. The Kaplan-Meier analysis of cumulative recurrence rate and recurrence-free survival revealed that the high-risk stage I colorectal cancer patients have poorer clinical outcomes than the low-risk patients.

conclusionAlthough stage I colorectal cancer patients generally have a favorable prognosis after curative surgery, poorer prognosis was observed in high-risk stage I colorectal cancer patients than in low-risk patients.

Indexed as

Colorectal NeoplasmsRectal NeoplasmsHumansJapanNeoplasm Recurrence, LocalNeoplasm StagingPrognosisProportional Hazards ModelsRetrospective StudiesColorectal cancerHigh riskRecurrenceStage I

Identifiers

PMID35588331
OpenAlexW4280534383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.