Evidence map›Paper›PMID 35588210›Full record

ArticleHypertension (Dallas, Tex. : 1979)2022

Reshaping the Preterm Heart: Shifting Cardiac Renin-Angiotensin System Towards Cardioprotection in Rats Exposed to Neonatal High-Oxygen Stress.

Mariane Bertagnolli, Daniela R Dartora, Pablo Lamata, Ernesto Zacur, Thuy-An Mai-Vo, Ying He, Léonie Beauchamp, Adam J Lewandowski, Anik Cloutier, Megan R Sutherland and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Cannabidiol Protects the Neonatal Mouse Heart from Hyperoxia-Induced Injury.International journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Mariane BertagnolliSainte-Justine University Hospital Research Center, Université de Montréal, Canada (M.B., D.R.D., T.-A.M.-V., Y.H., L.B., A.C., M.R.S., A.M.N.).ORCID 0000-0002-1093-1445
Daniela R DartoraSainte-Justine University Hospital Research Center, Université de Montréal, Canada (M.B., D.R.D., T.-A.M.-V., Y.H., L.B., A.C., M.R.S., A.M.N.).
Pablo LamataDepartment of Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering, King's College London, United Kingdom (P.L., E.Z.).ORCID 0000-0002-3097-4928
Ernesto ZacurDepartment of Biomedical Engineering, Division of Imaging Sciences and Biomedical Engineering, King's College London, United Kingdom (P.L., E.Z.).ORCID 0000-0001-9647-7417
Thuy-An Mai-VoSainte-Justine University Hospital Research Center, Université de Montréal, Canada (M.B., D.R.D., T.-A.M.-V., Y.H., L.B., A.C., M.R.S., A.M.N.).
Ying HeSainte-Justine University Hospital Research Center, Université de Montréal, Canada (M.B., D.R.D., T.-A.M.-V., Y.H., L.B., A.C., M.R.S., A.M.N.).
Léonie BeauchampSainte-Justine University Hospital Research Center, Université de Montréal, Canada (M.B., D.R.D., T.-A.M.-V., Y.H., L.B., A.C., M.R.S., A.M.N.).
Adam J LewandowskiOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom (A.J.L.).ORCID 0000-0002-4978-8965
Anik CloutierSainte-Justine University Hospital Research Center, Université de Montréal, Canada (M.B., D.R.D., T.-A.M.-V., Y.H., L.B., A.C., M.R.S., A.M.N.).
Megan R SutherlandSainte-Justine University Hospital Research Center, Université de Montréal, Canada (M.B., D.R.D., T.-A.M.-V., Y.H., L.B., A.C., M.R.S., A.M.N.).ORCID 0000-0002-0841-1635
Robson A S SantosDepartment of Physiology, Instituto Nacional de Ciência e Tecnologia - Nanobiofar, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil (R.A.S.S.).ORCID 0000-0001-8738-5852
Anne Monique NuytSainte-Justine University Hospital Research Center, Université de Montréal, Canada (M.B., D.R.D., T.-A.M.-V., Y.H., L.B., A.C., M.R.S., A.M.N.).ORCID 0000-0003-3791-006X
Centre Hospitalier Universitaire Sainte-Justine · CAKing's College London · GBDiscovery Institute · USJohn Radcliffe Hospital · GBUniversidade Federal de Minas Gerais · BR

Funding

British Heart Foundation FS/18/3/33292Wellcome Trust 209450/Z/17/Z
6 · The paper itself

Abstract

backgroundApproximately 10% of infants are born preterm. Preterm birth leads to short and long-term changes in cardiac shape and function. By using a rat model of neonatal high-oxygen (80%O

methodsSprague-Dawley pups were exposed to room air or 80% O

resultsAt P10, high O

conclusionsOur findings demonstrate LV remodeling changes induced by O

Indexed as

CardiomyopathiesCyclodextrinsPremature BirthAnimalsFemaleHumansInfant, NewbornMyocardiumOxygenRatsRats, Sprague-DawleyRenin-Angiotensin SystemVentricular RemodelingCyclodextrinsOxygenangiotensin-converting enzymecardiomyopathiescyclodextrinsechocardiographypremature birthrenin-angiotensin system

Identifiers

PMID35588210
PMCPMC9278707
OpenAlexW4281252408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.