Evidence map›Paper›PMID 35588002›Full record

ArticleChemMedChem2022

Synthesis and Evaluation of Functionalized Aryl and Biaryl Isothiocyanates against Human MCF-7 Cells.

Claire C Fanta, Kaitlyn J Tlusty, Sarah E Pauley, Amanda L Johnson, Genevieve A Benjamin, Taylor K Yseth, Michaela M Bunde, Paul T Pierce, Shirley Wang, Peter F Vitiello and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Claire C FantaDepartment of Chemistry & Biochemistry, Augustana University, 2001 S. Summit Ave., Sioux Falls, SD-57197, USA.
Kaitlyn J TlustyDepartment of Chemistry & Biochemistry, Augustana University, 2001 S. Summit Ave., Sioux Falls, SD-57197, USA.
Sarah E PauleyDepartment of Chemistry & Biochemistry, Augustana University, 2001 S. Summit Ave., Sioux Falls, SD-57197, USA.
Amanda L JohnsonDepartment of Chemistry & Biochemistry, Augustana University, 2001 S. Summit Ave., Sioux Falls, SD-57197, USA.
Genevieve A BenjaminDepartment of Chemistry & Biochemistry, Augustana University, 2001 S. Summit Ave., Sioux Falls, SD-57197, USA.
Taylor K YsethDepartment of Chemistry & Biochemistry, Augustana University, 2001 S. Summit Ave., Sioux Falls, SD-57197, USA.
Michaela M BundeDepartment of Chemistry & Biochemistry, Augustana University, 2001 S. Summit Ave., Sioux Falls, SD-57197, USA.
Paul T PierceDepartment of Pediatrics, Section of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, 1200 Everett Dr., Oklahoma City, OK-73014, USA.
Shirley WangDepartment of Pediatrics, Section of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, 1200 Everett Dr., Oklahoma City, OK-73014, USA.
Peter F VitielloDepartment of Pediatrics, Section of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, 1200 Everett Dr., Oklahoma City, OK-73014, USA.
Jared R MaysDepartment of Chemistry & Biochemistry, Augustana University, 2001 S. Summit Ave., Sioux Falls, SD-57197, USA.ORCID 0000-0002-6867-3581
Augustana University · USUniversity of Oklahoma Health Sciences Center · US

Funding

Wichozani-A Healthy Lifestyle for Rural American Indian Youth through Cultural and Physical Activities: A Community-Based Participatory Research StudyP20GM103443 · NIGMS · UNIVERSITY OF SOUTH DAKOTA · PI Victor Chester Huber · 2012 to 2026
$58.1M
WESTCORE DNA SEQUENCING AND GENOTYPING CORE FACILITYP20RR016479 · NCRR · UNIVERSITY OF SOUTH DAKOTA · PI GOODMAN, BARBARA EASON · 2001 to 2011
$32.2M
Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2M
The Impact of PD-1 Inhibition on Immune-Response to ChemoradiotherapyP20GM103548 · NIGMS · SANFORD RESEARCH/USD · PI MISKIMINS, W KEITH · 2012 to 2020
$20.8M
Hyperoxic Modulation of Thioredoxin SignalingR01HL135112 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI VITIELLO, PETER · 2017 to 2021
$2.0M
NCRR NIH HHS P20 RR016479NHLBI NIH HHS R01 HL135112NIGMS NIH HHS P20 GM103443NIGMS NIH HHS P20 GM103548NIGMS NIH HHS P20 GM103620
6 · The paper itself

Abstract

Organic isothiocyanates (ITCs) are a class of anticancer agents which naturally result from the enzymatic degradation of glucosinolates produced by Brassica vegetables. Previous studies have demonstrated that the structure of an ITC impacts its potency and mode(s) of anticancer properties, opening the way to preparation and evaluation of synthetic, non-natural ITC analogues. This study describes the preparation of a library of 79 non-natural ITC analogues intended to probe further structure-activity relationships for aryl ITCs and second-generation, functionalized biaryl ITC variants. ITC candidates were subjected to bifurcated evaluation of antiproliferative and antioxidant response element (ARE)-induction capacity against human MCF-7 cells. The results of this study led to the identification of (1) several key structure-activity relationships and (2) lead ITCs demonstrating potent antiproliferative properties.

Indexed as

Antineoplastic AgentsIsothiocyanatesAntioxidant Response ElementsHumansMCF-7 CellsStructure-Activity RelationshipAntineoplastic AgentsIsothiocyanatesantiproliferationAREisothiocyanateqPCRSAR

Identifiers

PMID35588002
PMCPMC9308763
OpenAlexW4280552183

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.