Evidence map›Paper›PMID 35587977›Full record

ArticleScience (New York, N.Y.)2022

Directed evolution of nonheme iron enzymes to access abiological radical-relay C(sp

Jinyan Rui, Qun Zhao, Anthony J Huls, Jordi Soler, Jared C Paris, Zhenhong Chen, Viktor Reshetnikov, Yunfang Yang, Yisong Guo, Marc Garcia-Borràs and 1 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
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  8. Article
  9. Article
  10. Examining Pseudohalide (NJournal of inorganic biochemistry · 2026
    Article
  11. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  12. Article
  13. Article
  14. Non-heme iron enzymes step into the spotlight.Nature chemical biology · 2025
    Article
  15. Bimolecular Homolytic Substitution (SACS central science · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jinyan Rui *Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-8001-4458
Qun Zhao *Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-7372-4195
Anthony J Huls *Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-6314-2175
Jordi SolerInstitut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus Montilivi, Girona E-17071 Catalonia, Spain.ORCID 0000-0002-3537-4227
Jared C ParisDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0001-9932-5208
Zhenhong ChenDepartment of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
Viktor ReshetnikovDepartment of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
Yunfang YangCollege of Chemical Enginering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.ORCID 0000-0002-6287-1640
Yisong GuoDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID 0000-0002-4132-3565
Marc Garcia-BorràsInstitut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus Montilivi, Girona E-17071 Catalonia, Spain.ORCID 0000-0001-9458-1114
Xiongyi HuangDepartment of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-7156-8881

Funding

A Chemo-Mimetic Platform to Reprogram Metalloenzymes for Non-Natural Biocatalytic C-H Functionalization ReactionsR35GM147639 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Xiongyi Huang · 2022 to 2026
$2.1M
Expanding the chemistry of life: New enzymatic platforms for synthesis of bioactive organofluorinesR00GM129419 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI HUANG, XIONGYI · 2020 to 2022
$747k
NIGMS NIH HHS R00 GM129419NIGMS NIH HHS R35 GM147639
6 · The paper itself

Abstract

We report the reprogramming of nonheme iron enzymes to catalyze an abiological C(sp

Indexed as

Directed Molecular EvolutionEnzymesNonheme Iron ProteinsBiocatalysisCarbonHydrogenCarbonEnzymesHydrogenNonheme Iron Proteins

Identifiers

PMID35587977
PMCPMC9933208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.