Evidence map›Paper›PMID 35587837›Full record

ArticleCellular and molecular life sciences : CMLS2022

Fgfr2b signaling is essential for the maintenance of the alveolar epithelial type 2 lineage during lung homeostasis in mice.

Negah Ahmadvand, Arun Lingampally, Farhad Khosravi, Ana Ivonne Vazquez-Armendariz, Stefano Rivetti, Matthew R Jones, Jochen Wilhelm, Susanne Herold, Guillermo Barreto, Janine Koepke and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

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  11. The lung mesenchyme in development, regeneration, and fibrosis.The Journal of clinical investigation · 2023
    Review
  12. Injury activated alveolar progenitors (IAAPs): the underdog of lung repair.Cellular and molecular life sciences : CMLS · 2023
    Review
  13. Simple Models of Lung Development.Advances in experimental medicine and biology · 2023
    Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Negah AhmadvandCardio-Pulmonary Institute and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, Germany.
Arun LingampallyCardio-Pulmonary Institute and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, Germany.
Farhad KhosraviDepartment of Physiology, Justus-Liebig University Giessen, Giessen, Germany.
Ana Ivonne Vazquez-ArmendarizCardio-Pulmonary Institute and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, Germany.
Stefano RivettiCardio-Pulmonary Institute and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, Germany.
Matthew R JonesCardio-Pulmonary Institute and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, Germany.
Jochen WilhelmCardio-Pulmonary Institute and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, Germany.
Susanne HeroldCardio-Pulmonary Institute and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, Germany.
Guillermo BarretoLaboratoire IMoPA, UMR 7365 CNRS, Biopole de l'Universite de Lorraine, 54505, Vandoeuvre-les-Nancy, France.
Janine KoepkeCardio-Pulmonary Institute and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, Germany.
Christos SamakovlisCardio-Pulmonary Institute and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University Giessen, Giessen, Germany.
Gianni CarraroDepartment of Medicine, Cedars-Sinai Medical Center, Lung and Regenerative Medicine Institutes, Los Angeles, CA, 90027, USA.
Jin-San ZhangThe Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, Zhejiang, China.
Denise Al AlamLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Los Angeles, CA, USA.
Saverio BellusciThe Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, Zhejiang, China. saverio.bellusci@innere.med.uni-giessen.de.ORCID http://orcid.org/0000-0001-5987-4579
Justus-Liebig-Universität Gießen · DEWenzhou Medical University · CNCedars-Sinai Medical Center · USCentre National de la Recherche Scientifique · FRUCLA Medical Center · US

Funding

Mechanisms controlling early human lung developmentR01HL141856 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI AL-ALAM, DENISE · 2018 to 2022
$2.5M
Deutsche Forschungsgemeinschaft BE4443/1-1Deutsche Forschungsgemeinschaft BE4443/4-1NHLBI NIH HHS R01 HL141856
6 · The paper itself

Abstract

Fibroblast growth factor receptor 2b (Fgfr2b) signaling is essential throughout lung development to form the alveolar epithelial lineage. However, its role in alveolar epithelial type 2 cells (AT2s) homeostasis was recently considered dispensable. Sftpc

Indexed as

LungReceptor, Fibroblast Growth Factor, Type 2Alveolar Epithelial CellsAnimalsCell DifferentiationHomeostasisMiceTamoxifenReceptor, Fibroblast Growth Factor, Type 2TamoxifenAlveolar epithelial progenitors activationAmplification and differentiationFgfr2bLineage tracingOrganoids

Identifiers

PMID35587837
PMCPMC9120111
OpenAlexW4280610229

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.