ArticleThe journal of nutrition, health & aging2022
Mediating Effects of Malnutrition on the Relationship between Depressive Symptoms Clusters and Muscle Function Rather than Muscle Mass in Older Hemodialysis Patients.
Article in The journal of nutrition, health & aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Latent class analysis of depression among maintenance hemodialysis patients in China: a multicenter cross-sectional study.Renal failure · 2025Article
- Molecular frontiers in hemodialysis: unraveling the role of membranes in gene expression, epigenetics, and inflammatory pathways.International urology and nephrology · 2025Review
- Associations of Nutritional Health Risk With Cognitive Function in Older Korean Adults: The Mediating Roles of Lower Body Strength and Depression.Geriatrics & gerontology international · 2025Article
- Sarcopenia and dynapenia are associated with depression rather than anxiety in Chinese hemodialysis patients.BMC psychiatry · 2025Article
- Investigating the association of bioelectrical impedance analysis-derived phase angle and depressive symptoms in patients receiving maintenance hemodialysis: a cross-sectional study.Frontiers in nutrition · 2025Article
- Association between Geriatric Nutrition Risk Index and depression in older hemodialysis patients with and without type 2 diabetes mellitus: a multicenter cross-sectional study.Frontiers in endocrinology · 2025Article
- Phase Angle as an Indicator of Depression in Maintenance Hemodialysis Patients.Kidney diseases (Basel, Switzerland) · 2024Article
- Short-physical performance battery: complete mediator of cognitive depressive symptoms and diabetes mellitus in hemodialysis patients.BMC public health · 2024Article
- Chest X-ray Findings and Prognostic Factors in Survival Analysis in Peritoneal Dialysis and Hemodialysis Patients: A Retrospective Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2024Article
- Association between Cognitive Impairment and Malnutrition in Hemodialysis Patients: Two Sides of the Same Coin.Nutrients · 2023Article
- Physical activity, physical frailty and depressive symptoms among Chinese male and female older adults: do different indicators make a difference?Frontiers in public health · 2023Article
- Physical performance and muscle strength rather than muscle mass are predictor of all-cause mortality in hemodialysis patients.Frontiers in public health · 2023Article
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Authors and funding
14 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this study was to investigate the association and mediation pathways among muscle mass, muscle function (muscle strength and physical performance), and malnutrition with depressive symptoms clusters in the older hemodialysis patients.
designA multi-center cross-sectional study. SETTING AND
participantsA total of 499 patients aged ≥ 60 on hemodialysis from seven facilities in Shanghai of China from 2020 to 2021. MEASUREMENTS: Muscle mass was assessed by skeletal muscle index(SMI). Muscle strength was measured by handgrip strength, and physical performance was measured via gait speed and Timed Up and Go Test (TUGT). Nutritional status was assessed by Malnutrition Inflammation Score (MIS). Depressive symptoms were evaluated by the Patient Health Questionnaire-9 (PHQ-9). Logistic regression and mediation analyses fully adjusted for all potential confounding factors.
resultsAmong 499 participants (312 men, mean age 69.2±6.6 years), 108 (21.6%) had depressive symptoms. The muscle strength, physical performance and malnutrition were associated with depressive symptoms. Furthermore, malnutrition significantly mediated the association of muscle function with total, cognitive-affective symptoms. The association of the muscle function with somatic symptoms were mediated by the nutritional status. The mediated proportions of malnutrition in the relationship between physical performance and depressive symptoms clusters were stronger in somatic symptoms than in cognitive-affective symptoms.
conclusionsOur findings suggest that muscle function rather than muscle mass may contribute substantially to the development of depressive symptoms clusters in the hemodialysis via malnutrition. The malnutrition mediated stronger in the association of muscle function with somatic symptoms. These findings may help guide clinicians to better diagnose and manage depression in the context of concomitant muscle function and malnutrition.
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