Evidence map›Paper›PMID 35587686›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

Identification of 1

Yin Sun, Haotian Tang, Xiaoyan Wang, Fang Feng, Tiantian Fan, Dongmei Zhao, Bing Xiong, Hua Xie, Tongchao Liu

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yin SunKey Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Haotian TangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
Xiaoyan WangKey Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Fang FengShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
Tiantian FanShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
Dongmei ZhaoKey Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China.
Bing XiongShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
Hua XieShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
Tongchao LiuShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China.
Shanghai Institute of Materia Medica · CNShenyang Pharmaceutical University · CNUniversity of Chinese Academy of Sciences · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

sABSTRACTTANK-binding kinase 1 (TBK1), a noncanonical member of the inhibitor-kappaB kinases (IKKs) family, plays a vital role in coordinating the signalling pathways of innate immunity, involving in the process of neuroinflammation, autophagy, and oncogenesis. In current study, based on rational drug design strategy, we discovered a series of 1

Indexed as

Protein Kinase InhibitorsPyridinesCell ProliferationDrug DesignMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipProtein Kinase InhibitorsPyridines1H-pyrazolo[3,4-b]pyridinecancer therapyimmune responsestructure–activity relationships (SARs)TBK1 inhibitors

Identifiers

PMID35587686
PMCPMC9132415
OpenAlexW4280611967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.