Trial reportClinical and translational science2022
Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term.
Trial report in Clinical and translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02408315 (Induction With Misoprostol), which is not on this map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Induction With Misoprostol: Oral Mucosa Versus Vaginal Epithelium
Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Pharmacokinetics of vaginal versus buccal misoprostol for labor induction at term.Clinical and translational science · 2022Trial
- In vitro metal leaching from tampons under simulated vaginal and menstrual pH conditions.AJOG global reports · 2026Article
- Comparative Analysis of In Vitro Permeation and Human Pharmacokinetic Data for a Bioadhesive Vaginal Tablet as a Potential Clinical Approach for Bacterial Vaginosis.Pharmaceutics · 2026Article
- Medication Abortion Failure in a Patient With Class III Obesity and Twin Gestation: A Case Report.Cureus · 2026Article
- Tampons as a source of exposure to metal(loid)s.Environment international · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
The IMPROVE study (NCT02408315) compared the efficacy and safety of vaginal and buccal administration of misoprostol for full-term, uncomplicated labor induction. This report compares the pharmacokinetics of misoprostol between vaginal and buccal routes. Women greater than or equal to 14 years of age undergoing induction of labor greater than or equal to 37 weeks gestation without significant complications were randomized to vaginal or buccal misoprostol 25 μg followed by 50 μg doses every 4 h. Misoprostol acid concentrations were determined using liquid chromatography-tandem mass spectrometry for the first 8 h in a subgroup of participants. A population pharmacokinetic model was developed using NONMEM. Plasma concentrations (n = 469) from 47 women were fit to a one-compartment nonlinear clearance model. The absorption rate constant (k
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.