ArticlePLoS computational biology2022
Linear viscoelastic properties of the vertex model for epithelial tissues.
Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Necking of epithelial tissues with cellular topological transition.PLoS computational biology · 2026Article
- Anisotropic Cellular Forces Drive Hexagonal-to-Tetragonal Tiling Transitions in the Drosophila Eye.Development, growth & differentiation · 2026Article
- Article
- Learning Epithelial Elasticity via Local Tension Remodeling.bioRxiv : the preprint server for biology · 2025Article
- Enhanced extracellular matrix remodeling due to embedded spheroid fluidization.New journal of physics · 2025Article
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- Cell-Level Modelling of Homeostasis in Confined Epithelial Monolayers.Journal Of Elasticity · 2025Article
- Spectral approaches to stress relaxation in epithelial monolayers.Proceedings. Mathematical, physical, and engineering sciences · 2024Article
- A two-dimensional vertex model for curvy cell-cell interfaces at the subcellular scale.Journal of the Royal Society, Interface · 2024Article
- iMaterials today. Bio · 2024Article
- Article
- Article
- Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading.Soft matter · 2022Article
- 3D viscoelastic drag forces contribute to cell shape changes during organogenesis in the zebrafish embryo.Cells & development · 2021Article
- Discontinuous Shear Thickening in Biological Tissue Rheology.Physical review. XArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Epithelial tissues act as barriers and, therefore, must repair themselves, respond to environmental changes and grow without compromising their integrity. Consequently, they exhibit complex viscoelastic rheological behavior where constituent cells actively tune their mechanical properties to change the overall response of the tissue, e.g., from solid-like to fluid-like. Mesoscopic mechanical properties of epithelia are commonly modeled with the vertex model. While previous studies have predominantly focused on the rheological properties of the vertex model at long time scales, we systematically studied the full dynamic range by applying small oscillatory shear and bulk deformations in both solid-like and fluid-like phases for regular hexagonal and disordered cell configurations. We found that the shear and bulk responses in the fluid and solid phases can be described by standard spring-dashpot viscoelastic models. Furthermore, the solid-fluid transition can be tuned by applying pre-deformation to the system. Our study provides insights into the mechanisms by which epithelia can regulate their rich rheological behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.