Evidence map›Paper›PMID 35587310›Full record

ArticleMolecular neurobiology2022

Propolis Promotes Memantine-Dependent Rescue of Cognitive Deficits in APP-KI Mice.

Shigeki Moriguchi, Ryo Inagaki, Takashi Saito, Takaomi C Saido, Kohji Fukunaga

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Protective Effects of a Propolis-Journal of microbiology and biotechnology · 2026
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Shigeki Moriguchi *Research Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan. shigeki.moriguchi.a3@tohoku.ac.jp.ORCID http://orcid.org/0000-0002-8147-0412
Ryo Inagaki *Research Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.
Takashi SaitoDepartment of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan.
Kohji FukunagaDepartment of CNS Drug Innovation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Tohoku University · JPNagoya City University · JPRIKEN Center for Brain Science · JP

Funding

The Ministry of Education, Culture, Sports, Science, and Technology, and the Ministry of Health and Welfare of Japan 18K06887The Project of Translational and Clinical Research Core Centers from AMED of Japan 21wm0525031h0001
6 · The paper itself

Abstract

Propolis is a complex resinous substance that is relevant as a therapeutic target for Alzheimer's disease (AD) and other neurodegenerative diseases. In this study, we confirmed that propolis (Brazilian green propolis) further enhances the rescue of cognitive deficits by the novel AD drug memantine in APP-KI mice. In memory-related behavior tasks, administration of a single dose of propolis at 1-100 mg/kg p.o. significantly enhanced the rescue of cognitive deficits by memantine at 1 mg/kg p.o. in APP-KI mice. In in vitro studies, propolis significantly increased intracellular Ca

Indexed as

Alzheimer DiseasePropolisAdenosine TriphosphateAnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2CognitionDisease Models, AnimalMemantineMiceMice, TransgenicAdenosine TriphosphateCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2MemantinePropolisAlzheimer’s diseaseCognitionKir6.2 channelMemantinePropolis

Identifiers

PMID35587310
OpenAlexW4280518499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.