Evidence map›Paper›PMID 35587274›Full record

GuidelineIntensive care medicine2022

Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline.

Morten H Møller, Waleed Alhazzani, Kimberley Lewis, Emilie Belley-Cote, Anders Granholm, John Centofanti, William B McIntyre, Jessica Spence, Zainab Al Duhailib, Dale M Needham and 16 more

Open access · greenAbstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Intensive care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
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  16. Review
  17. On the future of guidelines.Critical care (London, England) · 2025
    Article
  18. Article
  19. Sedation Practice in Intensive Care Evaluation, SPICE and beyond, Rinaldo's legacy in sedation and delirium research.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 20 institutions in 11 countries.

Morten H MøllerDepartment of Intensive Care, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. mortenhylander@gmail.com.ORCID http://orcid.org/0000-0002-6378-9673
Waleed AlhazzaniDivision of Critical Care, Department of Medicine, McMaster University, Hamilton, Canada.
Kimberley LewisDivision of Critical Care, Department of Medicine, McMaster University, Hamilton, Canada.
Emilie Belley-CoteDivisions of Cardiology and Critical Care, McMaster University, Hamilton, ON, Canada.
Anders GranholmDepartment of Intensive Care, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
John CentofantiDepartment of Anesthesia, McMaster University, Hamilton, ON, Canada.
William B McIntyrePopulation Health Research Institute, Hamilton, ON, Canada.
Jessica SpenceDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Zainab Al DuhailibDepartment of Critical Care Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Dale M NeedhamDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, USA.
Laura EvansDivision of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, USA.
Annika Reintam BlaserDepartment of Anaesthesiology and Intensive Care, University of Tartu, Tartu, Estonia.
Margaret A PisaniDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, 06501, USA.
Frederick D'AragonDepartment of Anesthesiology, Universite de Sherbrooke, Sherbrooke, QC, Canada.
Manu Shankar-HariCentre for Inflammation Research, The University of Edinburgh The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.
Mohammed AlshahraniDepartment of Emergency and Critical Care, College of Medicine, Imam Abdulrahman Ben Faisal University, Dammam, Saudi Arabia.
Giuseppe CiterioSchool of Medicine and Surgery, University Milano-Bicocca; Neurorianimazione, ASST-Monza, Monza, Italy.
Rakesh C AroraDepartment of Surgery, Section of Cardiac Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Sangeeta MehtaDepartment of Medicine, Sinai Health, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Timothy D GirardDepartment of Critical Care Medicine, Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Otavio T RanzaniBarcelona Institute for Global Health, ISGlobal, Barcelona, Spain.
Naomi HammondCritical Care Program, The George Institute for Global Health and UNSW Sydney, Newtown, NSW, Australia.
John W DevlinDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Yahya ShehabiDepartment of Intensive Care, Monash Health School of Clinical Sciences, Monash University, Clayton, VIC, 3168, Australia.
Pratik PandharipandeDivision of Anesthesiology Critical Care Medicine, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Marlies OstermannDepartment of Critical Care, King's College London, Guy's & St Thomas' Hospital, London, UK.
McMaster University · CACopenhagen University Hospital · DKImpact · CAASST Melegnano e della Martesana · ITBrigham and Women's Hospital · USCentre for Inflammation Research · GBHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRImam Abdulrahman Bin Faisal University · SAJohns Hopkins University · USKing Faisal Specialist Hospital & Research Centre · SAPopulation Health Research Institute · CARoyal North Shore Hospital · AUSt Thomas' Hospital · GBUniversité de Sherbrooke · CAUniversity of Lucerne · CHUniversity of Manitoba · CAUniversity of Pittsburgh · USUniversity of Toronto · CAUniversity of Washington · USUNSW Sydney · AU

Funding

Impact of Psychoactive Drugs on Delirium in ICU PatientsK23AG023023 · NIA · YALE UNIVERSITY · PI PISANI, MARGARET A · 2004 to 2008
$764k
Feasibility of Measuring Sleep in a Critical Care EnvironmentR21NR011066 · NINR · YALE UNIVERSITY · PI PISANI, MARGARET A · 2009 to 2010
$439k
NIA NIH HHS K23 AG023023NIA NIH HHS L30 AG022819NINR NIH HHS R21 NR011066
6 · The paper itself

Abstract

purposeThe aim of this Intensive Care Medicine Rapid Practice Guideline (ICM‑RPG) was to formulate evidence‑based guidance for the use of dexmedetomidine for sedation in invasively mechanically ventilated adults in the intensive care unit (ICU).

methodsWe adhered to the methodology for trustworthy clinical practice guidelines, including use of the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the certainty of evidence, and the Evidence-to-Decision framework to generate recommendations. The guideline panel comprised 28 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. Through teleconferences and web‑based discussions, the panel provided input on the balance and magnitude of the desirable and undesirable effects, the certainty of evidence, patients' values and preferences, costs and resources, feasibility, acceptability, and research priorities.

resultsThe ICM‑RPG panel issued one weak recommendation (suggestion) based on overall moderate certainty of evidence: "In invasively mechanically ventilated adult ICU patients, we suggest using dexmedetomidine over other sedative agents, if the desirable effects including a reduction in delirium are valued over the undesirable effects including an increase in hypotension and bradycardia".

conclusionThis ICM-RPG provides updated evidence-based guidance on the use of dexmedetomidine for sedation in mechanically ventilated adults, and outlines uncertainties and research priorities.

Indexed as

AnesthesiaDexmedetomidineAdultHumansHypnotics and SedativesIntensive Care UnitsRespiration, ArtificialDexmedetomidineHypnotics and SedativesClinical practice guidelineDexmedetomidineICM-RPGSedation

Identifiers

PMID35587274
OpenAlexW4280576941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.