Evidence map›Paper›PMID 35587273›Full record

ArticleThe Journal of membrane biology2022

Effect of Local Anesthetics on Dipole Potential of Different Phase Membranes: A Fluorescence Study.

Sandeep Shrivastava, Pankaj Ror, Amitabha Chattopadhyay

Abstract read
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In one paragraph

Article in The Journal of membrane biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sandeep ShrivastavaCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India.
Pankaj RorCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India.
Amitabha ChattopadhyayCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India. amit@ccmb.res.in.
Centre for Cellular and Molecular Biology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular mechanism behind the action of local anesthetics is not well understood. Phenylethanol (PEtOH) is an ingredient of essential oils with a rose-like odor, and it has previously been used as a local anesthetic. In this work, we explored the effect of PEtOH on dipole potential in membranes representing biologically relevant phases, employing the dual-wavelength ratiometric method utilizing the potential-sensitive probe di-8-ANEPPS. Our results show that PEtOH reduces membrane dipole potential in membranes of all biologically relevant phases (gel, liquid-ordered, and fluid) in a concentration-dependent manner. To the best of our knowledge, these results constitute one of the early reports describing reduction of membrane dipole potential induced by local anesthetics, irrespective of membrane phase.

Indexed as

Anesthetics, LocalPhenylethyl AlcoholFluorescenceMembrane PotentialsAnesthetics, LocalPhenylethyl AlcoholDi-8-ANEPPSDipolar reorganizationDipole potentialLocal anestheticsMembrane phasePhenylethanol

Identifiers

PMID35587273
OpenAlexW4280610742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.