ArticleNeuropsychopharmacology reports2022
Interaction between social behavior and paternal age in offspring of the same paternal mice.
Article in Neuropsychopharmacology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed, 4 citations in OpenAlex.
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- Interaction between social behavior and paternal age in offspring of the same paternal mice.Neuropsychopharmacology reports · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimPrevious studies reported that advanced paternal age (APA) may increase the risk of autism spectrum disorder (ASD) in offspring. However, effects of APA on behaviors have not been investigated in offspring of the same paternal mice. The present study sought to identify behavioral differences in mouse offspring of the same fathers at different paternal ages.
methodsWe assessed locomotor activity, anxiety-like behavior, and social behavior in male mouse offspring that were born from the same fathers at three different paternal ages (3, 12, and 15 months old).
resultsNo differences in locomotor activity or anxiety-like behavior were observed among any of the offspring groups. In the three-chamber test, although the control group (3-month-old paternal age) exhibited significantly higher approach behavior toward the novel mouse compared with the novel object, the APA groups (12- and 15-month-old paternal ages) did not exhibit significant approach toward the novel mouse.
conclusionOffspring of 3-month-old fathers but not 12- or 15-month-old APA fathers exhibited social preference behavior. Although the present study was only exploratory, it demonstrated an interaction between social behavior and paternal age in offspring of the same paternal mice.
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