Evidence map›Paper›PMID 35587206›Full record

ArticleMicrobiology spectrum2022

Gene-Based Diagnosis of Tuberculosis from Oral Swabs with a New Generation Pathogen Enrichment Technique.

Young Ae Kang, Bonhan Koo, Ock-Hwa Kim, Joung Ha Park, Ho Cheol Kim, Hyo Joo Lee, Myoung Gyu Kim, Youngwon Jang, Na Hyun Kim, Yong Seo Koo and 3 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. High-sensitivity detection ofJournal of clinical microbiology · 2025
    Article
  8. Review
  9. High-sensitivity detection ofmedRxiv : the preprint server for health sciences · 2024
    Article
  10. Review
  11. Tongue swab testing on two automated tuberculosis diagnostic platforms, Cepheid XpertmedRxiv : the preprint server for health sciences · 2023
    Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Young Ae Kang *Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, College of Medicine, Yonsei Universitygrid.15444.30, Seoul, Republic of Korea.
Bonhan Koo *Department of Biotechnology, College of Life Science and Biotechnology, Yonsei Universitygrid.15444.30, Seoul, Republic of Korea.
Ock-Hwa KimDepartment of Pulmonary and Critical Care Medicine, Asan Medical Centergrid.413967.e, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Joung Ha ParkDepartment of Infectious Diseases, Asan Medical Centergrid.413967.e, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Ho Cheol KimDepartment of Pulmonary and Critical Care Medicine, Asan Medical Centergrid.413967.e, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Hyo Joo LeeDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei Universitygrid.15444.30, Seoul, Republic of Korea.
Myoung Gyu KimDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei Universitygrid.15444.30, Seoul, Republic of Korea.
Youngwon JangDepartment of Pulmonary and Critical Care Medicine, Asan Medical Centergrid.413967.e, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Na Hyun KimDepartment of Pulmonary and Critical Care Medicine, Asan Medical Centergrid.413967.e, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Yong Seo KooDepartment of Neurology, Asan Medical Centergrid.413967.e, Seoul, Republic of Korea.
Yong Shin *Department of Biotechnology, College of Life Science and Biotechnology, Yonsei Universitygrid.15444.30, Seoul, Republic of Korea.
Sei Won Lee *Department of Pulmonary and Critical Care Medicine, Asan Medical Centergrid.413967.e, University of Ulsan College of Medicine, Seoul, Republic of Korea.ORCID 0000-0003-4814-6730
Sung-Han KimDepartment of Infectious Diseases, Asan Medical Centergrid.413967.e, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Ulsan College · KRYonsei University · KRAsan Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A rapid and sensitive diagnosis is crucial for the management of tuberculosis (TB). A simple and label-free approach via homobifunctional imidoesters with a microfluidic platform (SLIM) assay showed a higher sensitivity than the Xpert MTB/RIF assay in the diagnosis of pulmonary TB (PTB). Here, we evaluated the efficacy of the SLIM assay for oral swab samples from cases of suspected PTB. Patients with clinically suspected PTB were prospectively enrolled and oral swab samples were processed using the SLIM assay and the attending physicians were blinded to the results of the SLIM assay. TB cases were defined as those treated with anti-TB chemotherapy for at least 6 months at the discretion of the specialists based on their clinical features and conventional laboratory results, including the Xpert assay. A total of 272 patients (with TB,

Indexed as

Mycobacterium tuberculosisTuberculosisTuberculosis, PulmonaryHumansMiddle AgedRifampinSensitivity and SpecificityRifampingene-based diagnosisoral swabrapid diagnosistuberculosis

Identifiers

PMID35587206
PMCPMC9241603
OpenAlexW4280510934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.