Evidence map›Paper›PMID 35587198›Full record

ArticleInfection and immunity2022

The

R Clayton Bishop, Isabelle Derré

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Inclusion Membrane Proteins ofMicroorganisms · 2026
    Review
  2. Review
  3. mBio · 2024
    Article
  4. Recognition ofInfection and immunity · 2024
    Article
  5. Review
  6. Type III Secretion inMicrobiology and molecular biology reviews : MMBR · 2023
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Advances in genetic manipulation ofFrontiers in immunology · 2023
    Review
  13. Molecular pathogenesis ofFrontiers in cellular and infection microbiology · 2023
    Review
  14. Article
  15. The Type III Secretion Effector CteG Mediates Host Cell Lytic Exit ofFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

R Clayton BishopDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.
Isabelle DerréDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-7055-4346
University of Virginia · US

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
ER-Chlamydia Inclusion Membrane Contact SitesR01AI101441 · NIAID · YALE UNIVERSITY · PI DERRE, ISABELLE · 2014 to 2018
$2.0M
Host-pathogen interactions controlling Chlamydia developmental cycleR01AI162758 · NIAID · UNIVERSITY OF VIRGINIA · PI DERRE, ISABELLE · 2021 to 2025
$1.9M
Regulation and composition of ER-inclusion contacts at key stages of the Chlamydia developmental cycleR21AI166237 · NIAID · UNIVERSITY OF VIRGINIA · PI DERRE, ISABELLE · 2022 to 2023
$425k
NIAID NIH HHS R01 AI101441NIAID NIH HHS R01 AI162758NIAID NIH HHS R21 AI166237NIAID NIH HHS T32 AI007046
6 · The paper itself

Abstract

The obligate intracellular bacterium Chlamydia trachomatis is the causative agent of the most frequently reported bacterial sexually transmitted disease. Upon internalization into host cells, C. trachomatis remains within a membrane-bound compartment known as an inclusion, where it undergoes its developmental cycle. After completion of this cycle, bacteria exit the host cell. One mechanism of exit is lysis, whereby the inclusion and host cell rupture to release bacteria; however, the mechanism of lysis is not well characterized. A subset of C. trachomatis effectors, known as inclusion membrane proteins (Inc), are embedded within the inclusion membrane to facilitate host cell manipulation. The functions of many Inc proteins are unknown. We sought to characterize the Inc protein CTL0390. We determined that CTL0390 is expressed throughout the developmental cycle and that its C-terminal tail is exposed to the cytosol. To investigate the function of CTL0390, we generated a

Indexed as

Chlamydia InfectionsChlamydia trachomatisBacterial ProteinsCell DeathHeLa CellsHost-Pathogen InteractionsHumansMembrane ProteinsPlasmidsBacterial ProteinsMembrane Proteinsbacterial exitcGAS-STING pathwayChlamydia trachomatisCTL0390inclusion membrane proteinslysistype III effector proteins

Identifiers

PMID35587198
PMCPMC9202430
OpenAlexW4280575802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.