ArticleFrontiers in behavioral neuroscience2022
Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Hormonal and Behavioral Consequences of Social Isolation and Loneliness: Neuroendocrine Mechanisms and Clinical Implications.International journal of molecular sciences · 2025Review
- A vasopressin circuit that modulates mouse social investigation and anxiety-like behavior in a sex-specific manner.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A vasopressin circuit that modulates sex-specific social interest and anxiety-like behavior in mice.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hormones coordinate internal bodily systems with cognition, affect, and behavior, and thereby influence aspects of social interactions including cooperation, competition, isolation, and loneliness. The adaptive significance and contextuality of oxytocin (OXT) and testosterone (T) have been well-studied, but a unified theory and evolutionary framework for understanding the adaptive functions of arginine vasopressin (AVP) remain undeveloped. We propose and evaluate the hypothesis that AVP mediates adaptive variation in the presence and strength of social and sociosexual salience, attention and behavior specifically in situations that involve combinations of cooperation with conflict or competition. This hypothesis can help to explain the ancestral, original functions of AVP-like peptides, and their continuity with the current roles of AVP, for humans, in male-male competition, male-male reciprocity, male-to-female pair bonding, female-female interactions, social integration, and social attention and anxiety. In this context, social isolation and loneliness may be mediated by reduced abilities or interests in navigation of social opportunities and situations, due in part to low AVP levels or reactivity, and in part to reductions in levels of OXT-mediated social reward.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.