ArticleFrontiers in nutrition2022
Extraction of Bioactive Compounds From
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Extraction and Identification of Active Components fromMolecules (Basel, Switzerland) · 2025Article
- Genotype and chemotype insights of high-THC medicinal Cannabis sativa L.: the role of SSR markers in the identification of cultivars.Journal of cannabis research · 2025Article
- COSMO-RS Solubility Screening and Coumarin Extraction fromMolecules (Basel, Switzerland) · 2025Article
- Process Development for GMP-Grade Full Extract Cannabis Oil: Towards Standardized Medicinal Use.Pharmaceutics · 2025Article
- Development of a Validated LC-MS Method for the Determination of Cannabinoids and Evaluation of Supercritical COAntioxidants (Basel, Switzerland) · 2025Article
- Extraction of Cannabinoids and Terpenes from Hemp Flowers and Leaves (Molecules (Basel, Switzerland) · 2025Article
- Spontaneous Bio-Recycling: Recovering Bioactive Molecules Through Endogenous Microbial Maceration of Hemp Residues.Microorganisms · 2025Article
- Prospects in the Use ofBiotech (Basel (Switzerland)) · 2024Review
- Challenges of Extracting and Determining Cannabinoids in Different Matrices.Cannabis and cannabinoid research · 2024Review
- Effect of Hemp Extraction Procedures on Cannabinoid and Terpenoid Composition.Plants (Basel, Switzerland) · 2024Article
- The Potential of Hemp Extracts to Modify the Course of Oxidative-Stress Related Conditions.Plants (Basel, Switzerland) · 2024Article
- Water Extracts from Industrial Hemp Waste Inhibit the Adhesion and Development ofInternational journal of molecular sciences · 2024Article
- Determining Antioxidant Activity of Cannabis Leaves Extracts from Different Varieties-Unveiling Nature's Treasure Trove.Antioxidants (Basel, Switzerland) · 2023Article
- Isolation of Biologically Active Compounds fromAntioxidants (Basel, Switzerland) · 2023Article
- Deep Eutectic Solvents as a Green Tool for the Extraction of Bioactive Phenolic Compounds from Avocado Peels.Molecules (Basel, Switzerland) · 2022Article
- Pilot-Scale Preparation of Broad-Spectrum CBD: Extraction Optimization and Purification using Centrifugal Partition Chromatography.Medical cannabis and cannabinoidsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing demand for medical cannabis urges the development of new and effective methods for the extraction of phytocannabinoids. Deep eutectic solvents (DESs) are an alternative to the use of hazardous organic solvents typically used in the industry. In this study, hydrophilic and hydrophobic DESs were developed based on terpenes, sugars, and natural organic acids as green extraction media for the extraction of cannabis bioactive compounds. The factors influencing the extraction of bioactive components, such as the type of DESs and extraction time, were investigated. Initial screening in hemp showed that the DES composed of Men: Lau (a 2:1-M ratio) had a greater extraction efficiency of cannabidiol (CBD) and cannabidiolic acid (CBDA) (11.07 ± 0.37 mg/g) of all the tested DESs and higher than ethanol. Besides having a higher or equivalent extraction yield as the organic solvents tested, DESs showed to be more selective, extracting fewer impurities, such as chlorophyll and waxes. These results, coupled with the non-toxic, biodegradable, low-cost, and environmentally friendly characteristics of DESs, provide strong evidence that DESs represent a better alternative to organic solvents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.