Evidence map›Paper›PMID 35586594›Full record

ReviewJournal of ophthalmology2022

The Relationship between Statin and Risk of Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis.

Ezatollah Memarzadeh, Saeid Heidari-Soureshjani

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ezatollah MemarzadehDepartment of Ophthalmology, School of Medicine, Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.ORCID https://orcid.org/0000-0001-7872-1957
Saeid Heidari-SoureshjaniModeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.ORCID https://orcid.org/0000-0002-7592-3868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methods: Web of Science, PubMed, and Scopus databases were searched for articles that addressed the relationship between statin consumption and risk of AMD. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effects model. Subgroup analyses and sensitivity analyses were also conducted. Cochran's Results: In total, 22 studies were reviewed in the meta-analysis that included 2063195 participants and 313702 (15.20%) AMD patients compared to individuals not receiving statins. The OR of AMD in statin-receiving participants was 0.93 (95% CI; 0.83-1.05, Conclusion: According to the results of this study, taking statins does not increase or decrease the risk of AMD development. Therefore, this drug group cannot be considered a protective or risk factor for the occurrence of AMD.

Identifiers

PMID35586594
PMCPMC9110218

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.