ReviewJournal of multimorbidity and comorbidity2022
Association between pre-pregnancy multimorbidity and adverse maternal outcomes: A systematic review.
Review in Journal of multimorbidity and comorbidity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Global prevalence of multimorbidity during pregnancy: a systematic review and meta-analysis.Reproductive health · 2026Pooled it
- Perinatal and neonatal outcomes among women with multimorbidity during pregnancy globally: a systematic review.BMC pediatrics · 2026Pooled it
- The prevalence of mental health-related multimorbidity during pregnancy: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Severe maternal morbidity in patients with pre-existing diseases: a prospective observational cohort study (ForMaT trial).Scientific reports · 2026Observational
- Racial Disparities and Comorbidities: Network Analysis of Maternal Outcomes in Alabama.Journal of racial and ethnic health disparities · 2026Article
- 'It Was a Bit of a Now or Never Situation': Experiences of Preconception Care and Support for Women With Multiple Long-Term Health Conditions.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- The impact of antinuclear antibodies and complement levels in the prognosis of pregnant women within the antiphospholipid syndrome spectrum.Frontiers in immunology · 2026Article
- "I Feel Like a Lot of Black Women Don't Seek Preconception Health." Qualitative Findings of Preconception Health among Young Black Women in the United States.Journal of racial and ethnic health disparities · 2025Article
- Multimorbidity before, during and after pregnancy among women in low-income and middle-income countries: protocol for a scoping review.BMJ open · 2025Article
- Prevalence and patterns of pre-existing multimorbidity in pregnancy in Northern Ireland: a population-based, retrospective study using linked routinely collected healthcare data.BMC pregnancy and childbirth · 2025Article
- Changes in the prevalence of maternal chronic conditions during pregnancy: A nationwide age-period-cohort analysis.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Inclusion of people with multiple long-term conditions in pregnancy research: patient, public and stakeholder involvement and engagement in a randomised controlled trial.Research involvement and engagement · 2024Article
- Trends in the prevalence and pharmacological management of migraine during pregnancy in the UK, 2000-2018.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Impact of Inherited Thrombophilia in Women with Obstetric Antiphospholipid Syndrome: A Single-Center Study and Literature Review.Biomedicines · 2024Article
- Patient experiences with prenatal cell-free DNA screening in a safety net setting.Prenatal diagnosis · 2024Article
- Article
- Observational
- Advanced Midwifery Practice in Switzerland: Development and challenges.European journal of midwifery · 2024Article
- Maternal multimorbidity and preterm birth in Scotland: an observational record-linkage study.BMC medicine · 2023Observational
- The development of a core outcome set for studies of pregnant women with multimorbidity.BMC medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: We reviewed the literature on the association between pre-pregnancy multimorbidity (co-occurrence of two or more chronic conditions) and adverse maternal outcomes in pregnancy and postpartum. Data sources: Medline, EMBASE, and CINAHL were searched from inception to September, 2021. Study selection: Observational studies were eligible if they reported on the association between ≥ 2 co-occurring chronic conditions diagnosed before conception and any adverse maternal outcome in pregnancy or within 365 days of childbirth, had a comparison group, were peer-reviewed, and were written in English. Data extraction and synthesis: Two reviewers used standardized instruments to extract data and rate study quality and the certainty of evidence. A narrative synthesis was performed. Results: Of 6,381 studies retrieved, seven met our criteria. There were two prospective cohort studies, two retrospective cohort studies, and 3 cross-sectional studies, conducted in the United States (n=6) and Canada (n=1), and ranging in size from n=3,110 to n=57,326,681. Studies showed a dose-response relation between the number of co-occurring chronic conditions and risk of adverse maternal outcomes, including severe maternal morbidity or mortality, hypertensive disorders of pregnancy, and acute health care use in the perinatal period. Study quality was rated as strong (n=1), moderate (n=4), or weak (n=2), and the certainty of evidence was very low to moderate. Conclusion: Given the increasing prevalence of chronic disease risk factors such as advanced maternal age and obesity, more research is needed to understand the impact of pre-pregnancy multimorbidity on maternal health so that appropriate preconception and perinatal supports can be developed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.