Evidence map›Paper›PMID 35585986›Full record

ArticleFrontiers in immunology2022

Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy.

Andrea M H Towlerton, Shashidhar Ravishankar, David G Coffey, Camille E Puronen, Edus H Warren

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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  6. Dominant CD4Cell reports. Medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrea M H TowlertonClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Shashidhar RavishankarClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
David G CoffeyClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Camille E PuronenClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Edus H WarrenClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
University of Washington Medical Center · USFred Hutch Cancer Center · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Project 3U54CA190146 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CASPER, COREY · 2014 to 2019
$4.1M
High-Performance Compute Cluster for Comprehensive Cancer and Infectious Diseases ResearchS10OD028685 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BRADLEY, PHILIP · 2020 to 2020
$2.0M
NCI NIH HHS P30 CA015704NCI NIH HHS U54 CA190146NIAID NIH HHS P30 AI027757NIH HHS S10 OD028685
6 · The paper itself

Abstract

Long-term antiretroviral therapy (ART) in people living with HIV (PLHIV) is associated with sustained increases in CD4

Indexed as

HIV InfectionsReceptors, Antigen, T-Cell, alpha-betaAdultHigh-Throughput Nucleotide SequencingHumansLeukocytes, MononuclearViral LoadReceptors, Antigen, T-Cell, alpha-betaAntiretroviral therapy (ART)HIVImmune restorationT-cell repertoire analysisTCR sequencing

Identifiers

PMID35585986
PMCPMC9108698
OpenAlexW4225278787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.