Evidence map›Paper›PMID 35585902›Full record

ArticleParkinson's disease2022

Confirming Parkinson Disease Diagnosis: Patterns of Diagnostic Changes by Movement Disorder Specialists.

Marzieh Keshtkarjahromi, Danielle S Abraham, Ann L Gruber-Baldini, Katrina Schrader, Stephen G Reich, Joseph M Savitt, Rainer Von Coelln, Lisa M Shulman

Open access · goldAbstract read
In one paragraph

Article in Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Clinical and Imaging Characteristics of Parkinson's Disease with Negative Alpha-Synuclein Seed Amplification Assay.Movement disorders : official journal of the Movement Disorder Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Marzieh KeshtkarjahromiMedStar Health, Internal Medicine Residency Program, Department of Medicine, Baltimore, MD, USA.
Danielle S AbrahamUniversity of Pennsylvania, School of Medicine, Department of Neurology, Philadelphia, PA, USA.
Ann L Gruber-BaldiniUniversity of Maryland, School of Medicine, Department of Epidemiology and Public Health, Baltimore, MD, USA.
Katrina SchraderUniversity of Maryland, School of Medicine, Department of Neurology, Baltimore, MD, USA.
Stephen G ReichUniversity of Maryland, School of Medicine, Department of Neurology, Baltimore, MD, USA.
Joseph M SavittUniversity of Maryland, School of Medicine, Department of Neurology, Baltimore, MD, USA.
Rainer Von CoellnUniversity of Maryland, School of Medicine, Department of Neurology, Baltimore, MD, USA.
Lisa M ShulmanUniversity of Maryland, School of Medicine, Department of Neurology, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-1652-1201
University of Maryland, Baltimore · USMedStar Health · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The American Academy of Neurology Parkinson Disease (PD) quality measures include an annual diagnostic review. Objective: To investigate the frequency and pattern of changes in diagnoses between PD and other causes of parkinsonism. Methods: This prospective longitudinal cohort study included consented patients diagnosed with PD at least once and a minimum of two times at the Movement Disorders Center between 2002 and 2017. Movement disorder specialists confirmed and documented diagnoses at every visit. Longitudinal changes in diagnoses were identified across visits. Results: Of 1567 patients with parkinsonism, 174 had non-PD parkinsonism with no change over time. Of 1393 patients diagnosed with PD at least once, 94% ( Conclusion: Over a 15-year period, movement disorder specialists changed their clinical diagnosis of PD in 6% of patients. The most common diagnostic switches, to or from PD, were DIP, MSA, PSP, and DLB. This study describes routine clinical diagnostic patterns in the absence of pathologic confirmation. The presence of diverse diagnostic changes over time underscores the value of confirming PD diagnosis.

Identifiers

PMID35585902
PMCPMC9110256
OpenAlexW4229439162

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.