ArticleInternational journal of immunopathology and pharmacology
Relationship between toll-like receptor expression in the distal facial nerve and facial nerve recovery after injury.
Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Effect of Forward and Reverse Suturing on Nerve Regeneration Following Facial Nerve Axotomy.Biomedicines · 2024Article
- Expression of ChAT, Iba-1, and nNOS in the Central Nervous System following Facial Nerve Injury.Antioxidants (Basel, Switzerland) · 2024Article
- Electroacupuncture Promotes Functional Recovery after Facial Nerve Injury in Rats by Regulating Autophagy via GDNF and PI3K/mTOR Signaling Pathway.Chinese journal of integrative medicine · 2024Article
- Establishment of a facial nerve trunk crush injury model and evaluation of facial nerve self-healing in rats.Brain and behavior · 2023Article
- Expression and Role of Toll-like Receptors in Facial Nerve Regeneration after Facial Nerve Injury.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to determine whether toll-like receptor expression patterns differ in the distal facial nerve during recovery after crushing and cutting injuries.
methodsAdult male Sprague-Dawley rats underwent crushing or cutting injury of the unilateral facial nerve. Their whisker movement and blink reflex were examined. Western blotting was performed with the normal nerve on the left side and the damaged nerve on the right side, four days, 14 days, and 3 months after injury.
resultsThe scores of whisker movements and blink reflex in the crushing group showed improvements, while the score of the cutting group was significantly lower at 14 days and 3 months (p < 0.05). Western blotting showed that TLRs 11 and 13 increased in the crushing group, and TLRs 1, 2, 3, 4, 5, 8, 10, 11, 12, and 13 increased in the cutting group after 14 days (
conclusionTLRs 1, 4, 5, 8, and 12 are related to nerve degeneration after facial nerve injury, and TLRs 10, 11, and 13 are related to recovery from facial palsy.
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