ReviewHuman genomics2022
Genomic supremacy: the harm of conflating genetic ancestry and race.
Review in Human genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Integrating social determinants of health and genetic risk in disease risk models.American journal of human genetics · 2026Article
- Diversity, equity, and inclusion as scientific rigor: progress during challenging times.JNCI cancer spectrum · 2026Article
- Integrating genetic ancestry into clinical care: Accuracy, utility, and stakeholder views.Journal of community genetics · 2026Article
- Disparities associated with race and ethnicity in pain management: a scoping review.International journal of clinical pharmacy · 2026Article
- Genetically Estimated Ancestry and the Risk of Pre-Eclampsia: A Multiethnic Case-Control Study.JACC. Advances · 2025Article
- Narratives before numbers: Reimagining conversations about race, ethnicity, and ancestry information in genetic counseling practice.Journal of genetic counseling · 2025Article
- Machine learning models incorporating genotype and ancestry improve severe asthma risk prediction.Scientific reports · 2025Article
- Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort.Journal of exposure science & environmental epidemiology · 2025Article
- Race, ethnicity and ancestry in global diabetes research: grappling with complexity to advance equity and scientific integrity - a narrative review and viewpoint.Diabetologia · 2025Review
- A Scalable Framework to Integrate Social Determinants of Health into Disease Risk Models using Biobank Survey Data.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Social and Behavioral Genomics: On the Ethics of the Research and Its Downstream Applications.Annual review of genomics and human genetics · 2025Review
- Genetic Ancestry, Structural Racism, Social Determinants of Health, and Mortality Among Black Adults.JAMA network open · 2025Article
- Associations between in-home environmental exposures and lung function in a safety net population of children with asthma using electronic health records and geospatial data.Annals of epidemiology · 2025Article
- Experience using conventional compared to ancestry-based population descriptors in clinical genomics laboratories.American journal of human genetics · 2025Review
- Validating the Data Completeness and Accuracy of the Canadian Cystic Fibrosis Registry.Canadian respiratory journal · 2025Article
- Association of genetic ancestry with pre-eclampsia in multi-ethnic cohorts of pregnant women.Pregnancy hypertension · 2024Observational
- Can Open Science Advance Health Justice? Genomic Research Dissemination in the Evolving Data-Sharing Landscape.The Hastings Center report · 2024Article
- Race as a Risk Marker, Not a Risk Factor: Revising Race-Based Algorithms to Protect Racially Oppressed Patients.Journal of general internal medicine · 2024Article
- Impact of Skin Care Products on Phthalates and Phthalate Replacements in Children: the ECHO-FGS.Environmental health perspectives · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have reignited the tinderbox of debate surrounding the use of race and ancestry in medicine. These controversial studies have argued for a strong correlation between genetic ancestry and race, justifying continued use of genetic ancestry measures in studies of disease. These studies contend that increased use of continental ancestry estimates can inform clinical risk assessments and management. Further, recent studies of racial corrections used in clinical algorithms, such as those used to estimate 'normal' lung function, also advocate for use of genetic ancestry in place of race for refining risk algorithms. MAIN BODY: These positions are misleading, harmful, and reflect superficial interpretations of population genetics. In this Perspective, we argue that continental genetic ancestry, often proxied by race, serves as a poor indicator of disease risk, and reinforces racialized inequities.
conclusionInstead, we endorse that racial disparities in disease should be investigated by rigorous measures of structural racism alongside careful measures of genetic factors in relevant disease pathways, rather than relying on genetic ancestry or race as a crude proxy for disease-causing alleles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.