ArticleAlzheimer's research & therapy2022
Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort.
Article in Alzheimer's research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Selected social and lifestyle correlates of brain health markers: the Cross-Cohort Collaboration Consortium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.Alzheimer's research & therapy · 2026Article
- Evaluating the association of physical frailty with cognitive impairment: a clinical perspective in older adults of Bangladesh.BMC geriatrics · 2026Article
- A network analysis of dietary patterns, social participation patterns, and cognitive function in Chinese older adults.Frontiers in psychiatry · 2026Article
- A lifespan perspective on cognitive reserve and risk for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Were young men picking pets over people? Association between social network and pet ownership: A population-based study.One health (Amsterdam, Netherlands) · 2025Article
- Investigating the Relationships Between Neurodegenerative Diseases and Cancer Types: A Computational Approach.Current Alzheimer research · 2025Article
- Effects of physical activity dose on cognitive ability in Chinese adolescent students: parallel mediating roles of sleep quality and smartphone addiction.Frontiers in psychology · 2025Article
- Association between dietary vitamin B1 intake and cognitive function among older adults: a cross-sectional study.Journal of translational medicine · 2024Observational
- Global rural health disparities in Alzheimer's disease and related dementias: State of the science.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- Individuals with High Metacognitive Ability Are Better at Divergent and Convergent Thinking.Journal of Intelligence · 2023Article
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Authors and funding
21 authors at 12 institutions in 2 countries.
Funding
Abstract
backgroundThis work aimed to investigate the potential pathways involved in the association between social and lifestyle factors, biomarkers of Alzheimer's disease and related dementia (ADRD), and cognition.
methodsThe authors studied 2323 participants from the Memento study, a French nationwide clinical cohort. Social and lifestyle factors were education level, current household incomes, physical activity, leisure activities, and social network from which two continuous latent variables were computed: an early to midlife (EML) and a latelife (LL) indicator. Brain magnetic resonance imaging (MRI), lumbar puncture, and amyloid-positron emission tomography (PET) were used to define three latent variables: neurodegeneration, small vessel disease (SVD), and AD pathology. Cognitive function was defined as the underlying factor of a latent variable with four cognitive tests. Structural equation models were used to evaluate cross-sectional pathways between social and lifestyle factors and cognition.
resultsParticipants' mean age was 70.9 years old, 62% were women, 28% were apolipoprotein-ε4 carriers, and 59% had a Clinical Dementia Rating (CDR) score of 0.5. Higher early to midlife social indicator was only directly associated with better cognitive function (direct β = 0.364 (0.322; 0.405), with no indirect pathway through ADRD biomarkers (total β = 0.392 (0.351; 0.429)). In addition to a direct effect on cognition (direct β = 0.076 (0.033; 0.118)), the association between latelife lifestyle indicator and cognition was also mostly mediated by an indirect effect through lower neurodegeneration (indirect β = 0.066 (0.042; 0.090) and direct β = - 0.116 (- 0.153; - 0.079)), but not through AD pathology nor SVD.
conclusionsEarly to midlife social factors are directly associated with higher cognitive functions. Latelife lifestyle factors may help preserve cognitive functions through lower neurodegeneration.
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