ArticleBMC ophthalmology2022
Corneal higher-order aberration changes after accelerated cross-linking for keratoconus.
Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Evaluation of an allied health professionals-led keratoconus service in a tertiary UK centre.Eye (London, England) · 2026Article
- Effect of Accelerated Epi-Off Crosslinking on Optical Quality, Corneal Aberrations, and Epithelial Wavefront During Adolescence.Turkish journal of ophthalmology · 2026Article
- Prevalence of Keratoconus and Associated Risk Factors Among High School Students in Couva, Trinidad: A Cross-Sectional Study.Vision (Basel, Switzerland) · 2025Article
- Self-reported prevalence and risk factors associated with keratoconus among the adult population of Trinidad and Tobago: a cross-sectional study.International ophthalmology · 2025Article
- The Combined Utilization of Epithelial Thickness and Tomographic Parameters in Keratoconus Detection.Journal of ophthalmology · 2025Article
- Non-orthogonal spectacle correction for irregular astigmatism.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Corneal aberrations are associated with low-energy meniscus injuries.BMC ophthalmology · 2024Observational
- Corneal higher order aberrations by Sirius topography and their relation to different refractive errors.BMC ophthalmology · 2023Observational
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate changes in corneal higher-order aberrations (HOAs) following epithelium-off accelerated corneal cross-linking (A-CXL) and to explore the impact on visual acuity.
methodsIn this retrospective case series, 32 eyes of 24 patients with keratoconus (KC) underwent A-CXL. Treatment was delivered at 10 mW/cm
resultsAt one year post CXL, UDVA and CDVA were significantly improved, -0.13 ± 0.19 LogMAR (P = 0.0005) and -0.08 ± .0.11 LogMAR (P = 0.0003), respectively. The mean preoperative trefoil, secondary trefoil, secondary coma and secondary astigmatism were 0.95 ± 0.46; µm, 0.20 ± 0.11; µm, 0.29 ± 0.19; µm and 0.42 ± 0.17 µm, respectively. At one year, the mean values decreased significantly to 0.77 ± 0.47 µm, 0.15 ± 0.11 µm, 0.25 ± 0.18 µm and 0.34 ± 0.18 µm, respectively (P < 0.05, for all). No independent relationship between any HOA changes and change in UDVA was observed. A reduction in secondary coma aberration was associated with a change in CDVA (95% CI 0.01-1.34, P = 0.048; β = 0.67).
conclusionA 9-min protocol of Accelerated corneal cross-linking is an effective treatment in improving corneal HOAs at 12 months follow up, in eyes with progressive keratoconus at one year follow-up. A change in secondary coma had a statistically significant and independent effect on CDVA.
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