Evidence map›Paper›PMID 35585249›Full record

ArticleArchives of microbiology2022

Genomic characterization of three bacteriophages targeting multidrug resistant clinical isolates of Escherichia, Klebsiella and Salmonella.

Roshan Nepal, Ghais Houtak, Sumeena Karki, Gunaraj Dhungana, Sarah Vreugde, Rajani Malla

Open access · hybridAbstract read
In one paragraph

Article in Archives of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  7. Review
  8. New Bacteriophages Members of thePHAGE (New Rochelle, N.Y.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Roshan NepalFaculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia. roshan.nepal@adelaide.edu.au.ORCID http://orcid.org/0000-0002-5469-3397
Ghais HoutakFaculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.
Sumeena KarkiCentral Department of Biotechnology, Tribhuvan University, Kirtipur, Nepal.
Gunaraj DhunganaCentral Department of Biotechnology, Tribhuvan University, Kirtipur, Nepal.
Sarah VreugdeFaculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia.
Rajani MallaCentral Department of Biotechnology, Tribhuvan University, Kirtipur, Nepal.
Basil Hetzel Institute · AUTribhuvan University · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Application of bacteriophages (phages) to treat complex multidrug-resistant bacterial infection is gaining traction because of its efficacy and universal availability. However, as phages are specific to their host, a diverse collection of locally isolated phage from various geographical locations is required to formulate a wide host range phage cocktail. Here, we report morphological and genomic features of three newly isolated phages from river water of the urban region in Kathmandu, Nepal, targeting three different bacteria (Escherichia coli, Klebsiella pneumoniae and Salmonella enterica.) from the Enterobacteriaceae family. Morphological identification and genome analysis indicated that two phages (Escherichia phage vB_EcoM_TU01 and Klebsiella phage vB_KpnP_TU02) were strictly lytic and free from integrases, virulence factors, toxins and known antimicrobial resistance genes, whereas Salmonella phage vB_SalS_TU03 was possibly a temperate phage. The genomic features of these phages indicate that natural phages are capable of lysing pathogenic bacteria and may have potential in bacterial biocontrol.

Indexed as

BacteriophagesEscherichia coliGenome, ViralGenomicsHost SpecificityKlebsiellaSalmonellaBacteriophageEnterobacteriaceaeGenomicsPhagePhage therapy

Identifiers

PMID35585249
PMCPMC9117343
OpenAlexW4280524591

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.