ArticleNature2022
MCM complexes are barriers that restrict cohesin-mediated loop extrusion.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
96 citing papers in PubMed, 137 citations in OpenAlex.
- Nested TAD hierarchy defines cohesion zones on replicated chromosomes.The EMBO journal · 2026Article
- Folding a broken genome: the versatile roles of cohesin in genome maintenance.Nature reviews. Genetics · 2026Review
- Article
- A CThe New phytologist · 2026Article
- Direct visualization of MCM helicase activation and replisome coupling in situ.bioRxiv : the preprint server for biology · 2026Article
- Diverse Roles of Cohesin in Chromosome Dynamics and Stem Cells.Biotech (Basel (Switzerland)) · 2026Review
- Modeling the spatial organization of replicated chromosomes in yeast reveals a loose asymmetric cohesion between sister chromatids.Nucleic acids research · 2026Article
- Pioneer transcription factors direct tissue-specific cohesin chromatin entry and three-dimensional genome organization.Nature genetics · 2026Article
- NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- MCM2-7 proteins promote NF-κB transcriptional activity through cooperative promoter recruitment.Bioscience reports · 2026Article
- RepliSage: a stochastic graph-based framework for 3D chromatin modeling across the cell cycle.Nucleic acids research · 2026Article
- Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation.Nature communications · 2026Article
- Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption.Molecular cell · 2026Article
- Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity.Briefings in bioinformatics · 2026Article
- Condensin loop extrusion properties, roadblocks, and role in homology search during recombination in S. cerevisiae.The EMBO journal · 2026Article
- The 3D genomics of lampbrush chromosomes highlights the role of active transcription in chromatin organization.Nucleic acids research · 2026Article
- A functional overlap between actively transcribed genes and chromatin insulator elements.The EMBO journal · 2026Article
- Chromatin-intrinsic mechanisms determine orientation-specific class switch recombination.Nature communications · 2026Article
- Extrusion fountains are hallmarks of chromosome organization emerging upon zygotic genome activation.Nature communications · 2026Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 4 countries.
Bart J H Dequeker *Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0001-7975-2245
Matthias J Scherr *Structure and Dynamics of Molecular Machines, Max Planck Institute of Biochemistry (MPIB), Martinsried, Germany.ORCID http://orcid.org/0000-0003-0110-3709
Hugo B BrandãoHarvard Program in Biophysics, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5496-0638
Johanna GasslerInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0002-4408-6577
Sean PowellInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria.
Imre GasparDepartment of Totipotency, Max Planck Institute of Biochemistry (MPIB), Martinsried, Germany.
Ilya M FlyamerMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, UK.
Aleksandar LalicDepartment of Totipotency, Max Planck Institute of Biochemistry (MPIB), Martinsried, Germany.ORCID http://orcid.org/0000-0001-5250-3556
Wen TangResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.
Roman StocsitsResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0002-9478-3928
Iain F DavidsonResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0003-4945-6415
Jan-Michael PetersResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0003-2820-3195
Karl E DuderstadtStructure and Dynamics of Molecular Machines, Max Planck Institute of Biochemistry (MPIB), Martinsried, Germany. duderstadt@biochem.mpg.de.ORCID http://orcid.org/0000-0002-1279-7841
Leonid A MirnyDepartment of Physics, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. leonid@mit.edu.ORCID http://orcid.org/0000-0002-0785-5410
Kikuë TachibanaInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Vienna, Austria. tachibana@biochem.mpg.de.ORCID http://orcid.org/0000-0002-6564-7484
Institute of Molecular Biotechnology · ATMax Planck Institute of Biochemistry · DEResearch Institute of Molecular Pathology · ATHarvard University · USIIT@MIT · USInstitute of Genetics and Cancer · GB
Funding
Center for 3D Structure and Physics of the GenomeU54DK107980 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB · 2015 to 2019
$14.9MAustrian Science Fund FWF P 30613Medical Research Council MC_UU_00007/2NIDDK NIH HHS U54 DK107980NIH HHS DK107980
Abstract
Eukaryotic genomes are compacted into loops and topologically associating domains (TADs)
Indexed as
Cell Cycle ProteinsChromosomal Proteins, Non-HistoneDNAMinichromosome Maintenance ProteinsAnimalsCCCTC-Binding FactorChromatidsCohesinsG1 PhaseHCT116 CellsHumansMiceMinichromosome Maintenance Complex Component 3Multienzyme ComplexesNucleic Acid ConformationSaccharomyces cerevisiaeCCCTC-Binding FactorCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsCtcf protein, mouseDNAMCM3 protein, humanMinichromosome Maintenance Complex Component 3Minichromosome Maintenance ProteinsMultienzyme ComplexesSaccharomyces cerevisiae Proteins
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.