Evidence map›Paper›PMID 35585088›Full record

ArticleScientific data2022

A compilation of fecal microbiome shotgun metagenomics from hematopoietic cell transplantation patients.

Jinyuan Yan, Chen Liao, Bradford P Taylor, Emily Fontana, Luigi A Amoretti, Roberta J Wright, Eric R Littmann, Anqi Dai, Nicholas Waters, Jonathan U Peled and 8 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  4. Review
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  7. Microbiota and metabolic adaptation shapebioRxiv : the preprint server for biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jinyuan YanProgram for Computational and Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. yanj2@mskcc.org.ORCID 0000-0003-2046-5625
Chen LiaoProgram for Computational and Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-8474-1196
Bradford P TaylorCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Emily FontanaInfectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, New York, NY, USA.
Luigi A AmorettiInfectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, New York, NY, USA.
Roberta J WrightInfectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, New York, NY, USA.
Eric R LittmannDuchossois Family Institute, University of Chicago, Chicago, IL, USA.
Anqi DaiAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nicholas WatersAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9035-2143
Jonathan U PeledAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-4029-7625
Ying TaurInfectious Disease Service, Department of Medicine, and Immunology Program, Sloan Kettering Institute, New York, NY, USA.
Miguel-Angel PeralesAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-5910-4571
Benjamin A SiranosianDepartment of Genetics, Stanford University, Stanford, CA, USA.
Ami S BhattDepartment of Genetics, Stanford University, Stanford, CA, USA.
Marcel R M van den BrinkAdult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-0696-4401
Eric G PamerDuchossois Family Institute, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-6755-9904
Jonas SchluterInstitute for Computational Medicine, Department of Microbiology, New York University, New York, NY, USA.ORCID 0000-0002-6214-9367
Joao B XavierProgram for Computational and Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. xavierj@mskcc.org.ORCID 0000-0003-3592-1689

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Systems Biology of Microbiome-mediated Resilience to Antibiotic-resistant PathogensU01AI124275 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI PAMER, ERIC G., XAVIER, JOAO · 2016 to 2020
$8.9M
Mathematical ecology models of host-microbiota interaction in auto microbiota transplants (auto-FMT)R01AI137269 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI TAUR, YING, XAVIER, JOAO · 2019 to 2023
$3.8M
Microbiota mechanisms and biomarkers in GVHDK08HL143189 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI PELED, JONATHAN · 2019 to 2023
$858k
Mathematical ecology models of host-microbiota interaction in auto microbiota transplants (auto-FMT)R56AI137269 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI TAUR, YING, XAVIER, JOAO · 2018 to 2018
$429k
NCI NIH HHS P30 CA008748NHLBI NIH HHS K08 HL143189NIAID NIH HHS R01 AI137269NIAID NIH HHS R56 AI137269NIAID NIH HHS U01 AI124275
6 · The paper itself

Abstract

Hospitalized patients receiving hematopoietic cell transplants provide a unique opportunity to study the human gut microbiome. We previously compiled a large-scale longitudinal dataset of fecal microbiota and associated metadata, but we had limited that analysis to taxonomic composition of bacteria from 16S rRNA gene sequencing. Here we augment those data with shotgun metagenomics. The compilation amounts to a nested subset of 395 samples compiled from different studies at Memorial Sloan Kettering. Shotgun metagenomics describes the microbiome at the functional level, particularly in antimicrobial resistances and virulence factors. We provide accession numbers that link each sample to the paired-end sequencing files deposited in a public repository, which can be directly accessed by the online services of PATRIC to be analyzed without the users having to download or transfer the files. Then, we show how shotgun sequencing enables the assembly of genomes from metagenomic data. The new data, combined with the metadata published previously, enables new functional studies of the microbiomes of patients with cancer receiving bone marrow transplantation.

Indexed as

FecesHematopoietic Stem Cell TransplantationMicrobiotaHumansMetagenomicsRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID35585088
PMCPMC9117330

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.