ArticleNature communications2022
The planarian wound epidermis gene equinox is required for blastema formation in regeneration.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A flexible repertoire of wound closure strategies precedes whole-body regeneration.Nature communications · 2026Article
- Lack of specificity of planarian progenitor responses to injury in regeneration.bioRxiv : the preprint server for biology · 2026Article
- TIP60 acts as a wound-induced factor essential for efficient regeneration in planaria.The Journal of biological chemistry · 2026Article
- Deciphering the ancestral mechanisms of neural regeneration through single-cell analyses of jellyfish rhopalium repair.Science advances · 2026Article
- Immune surveillance on the insect body surface recognizes a pathogen-derived fungal protease to activate defenses.Nature communications · 2026Article
- Single-cell transcriptomics and RNAi screening define a hierarchical program of planarian eye regeneration.Cell reports · 2026Article
- 4D single-cell spatial transcriptomics reveals dynamic morphogenetic gradients and regenerative domains in planarians.GigaScience · 2026Article
- Developmental Toxicity of Ibrutinib: Insights from Stem Cell Dynamics and Neural Regeneration in Planarians.Biomolecules · 2025Article
- The planarian dorsal-ventral boundary regulates anterior-posterior axis growth and patterning.PLoS biology · 2025Article
- egal-1 and microtubules promote regeneration polarity in planarians.Development (Cambridge, England) · 2025Article
- Planarian microtubules form a network within muscle and regulate injury-induced genes essential for regeneration patterning.Development (Cambridge, England) · 2025Article
- Article
- Molecular Mechanism of Metformin Regulating the Regeneration of PlanarianInternational journal of molecular sciences · 2025Article
- Article
- Extracellular Vesicles Derived From Regenerating Tissue Promote Stem Cell Proliferation in the PlanarianJournal of extracellular biology · 2025Article
- DjsoxP-1 and Djsox5 are essential for tissue homeostasis and regeneration in Dugesia japonica.Cell and tissue research · 2025Article
- Coordinated neuron-glia regeneration through Notch signaling in planarians.PLoS genetics · 2025Article
- Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium.bioRxiv : the preprint server for biology · 2024Article
- Fibrillarin homologs regulate translation in divergent cell lineages during planarian homeostasis and regeneration.The EMBO journal · 2024Article
- Amputation Triggers Long-Range Epidermal Permeability Changes in Evolutionarily Distant Regenerative Organisms.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
4 authors.
Funding
Abstract
Regeneration often involves the formation of a blastema, an outgrowth or regenerative bud formed at the plane of injury where missing tissues are produced. The mechanisms that trigger blastema formation are therefore fundamental for regeneration. Here, we identify a gene, which we named equinox, that is expressed within hours of injury in the planarian wound epidermis. equinox encodes a predicted secreted protein that is conserved in many animal phyla. Following equinox inhibition, amputated planarians fail to maintain wound-induced gene expression and to subsequently undergo blastema outgrowth. Associated with these defects is an inability to reestablish lost positional information needed for missing tissue specification. Our findings link the planarian wound epidermis, through equinox, to regeneration of positional information and blastema formation, indicating a broad regulatory role of the wound epidermis in diverse regenerative contexts.
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