ArticleJournal of atherosclerosis and thrombosis2023
Relationships between Age at Menarche and Risk of Cardiovascular Disease Mortality among Japanese Women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study.
Article in Journal of atherosclerosis and thrombosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early Menarche as a Protective Factor Against Cardiovascular Events: A Systematic Review and Meta-analysis.Anatolian journal of cardiology · 2024Pooled it
- The J shaped association of age at menarche and cardiovascular events: systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Early in, early out: reproductive lifespan timing and cardiometabolic risk in women.Journal of endocrinological investigation · 2026Review
- Trends in meat consumption and its association with menarche timing: findings from CHNS 1997-2015.Scientific reports · 2025Article
- Age at menarche and risk of premature coronary artery disease: results from Iran premature coronary disease (IPAD) study.Archives of gynecology and obstetrics · 2025Article
- Association of Female Reproductive Factors with Incident Cardiometabolic Disease: Finding from a European Population-Based Study.Global heart · 2025Article
- Association of Age at Menarche with General and Abdominal Obesity in Young Women.Medicina (Kaunas, Lithuania) · 2024Article
- Reproductive factors and risk of cardiovascular outcomes in women with ST-elevation myocardial infarction.BMC pregnancy and childbirth · 2024Article
- Female Reproductive Events and Subclinical Atherosclerosis of the Brain and Carotid Arteriopathy: the Ohasama Study.Journal of atherosclerosis and thrombosis · 2023Article
- Women's reproductive traits and ischemic stroke: a two-sample Mendelian randomization study.Annals of clinical and translational neurology · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIn this study, we aimed to evaluate the association between age at menarche and risk of cardiovascular disease mortality.
methodsIn total, 54,937 women aged 40-79 years old between 1988 and 1990 without a history of cardiovascular disease were eligible for analysis and were followed through December 2009. We used the Cox proportional hazards models to examine the association between age at menarche and risk of cardiovascular disease.
resultsCompared with women with age at menarche of 15 years, the hazard ratios (95% confidence intervals) of stroke were 1.22 (0.85-1.75) for women with age at menarche of 9-12 years, 1.08 (0.85-1.36) for those of 13 years, 1.23 (1.02-1.47) for those of 14 years, 1.27 (1.07-1.50) for those of 16 years, 1.16 (0.95-1.41) for those of 17 years, and 1.39(1.16-1.68) for those of 18-20 years (P for trend=0.045). A similar pattern was observed for hemorrhagic stroke, ischemic stroke, and total cardiovascular disease. No such association was found for coronary heart disease. When stratified by age, for women aged 40-59 at baseline, the similar U-shaped association was observed. In contrast, for women aged 60-79 years at baseline, a significantly high hazard ratio was noted in the group of late age at menarche, but not in the group of early age at menarche.
conclusionsBoth women with early and late age at menarche were determined to have higher risk of death from stroke and cardiovascular disease.
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