Evidence map›Paper›PMID 35584879›Full record

ArticleBMJ open2022

Prevalence, geographical distribution and factors associated with pentavalent vaccine zero dose status among children in Sindh, Pakistan: analysis of data from the 2017 and 2018 birth cohorts enrolled in the provincial electronic immunisation registry.

Mariam Mehmood, Hamidreza Setayesh, Danya Arif Siddiqi, Muhammad Siddique, Sundus Iftikhar, Riswana Soundardjee, Vijay Kumar Dharma, Ahsanullah Khan Bhurgri, E M Stuckey, Muhammad Akram Sultan and 1 more

Abstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mariam MehmoodMaternal & Child Health, IRD Pakistan, Karachi, Pakistan.
Hamidreza SetayeshGavi, The Vaccine Alliance, Geneva, Switzerland.ORCID 0000-0003-1691-0298
Danya Arif SiddiqiIRD Global, Singapore.
Muhammad SiddiqueMaternal & Child Health, IRD Pakistan, Karachi, Pakistan.
Sundus IftikharMaternal & Child Health, IRD Pakistan, Karachi, Pakistan.
Riswana SoundardjeeGavi, The Vaccine Alliance, Geneva, Switzerland.
Vijay Kumar DharmaMaternal & Child Health, IRD Pakistan, Karachi, Pakistan.
Ahsanullah Khan BhurgriExpanded Program on Immunization, Sindh, Karachi, Pakistan.
E M StuckeyPolio, Bill & Melinda Gates Foundation, Seattle, Washington, USA.
Muhammad Akram SultanDepartment of Health, Government of Sindh, Karachi, Pakistan.
Subhash ChandirMaternal & Child Health, IRD Pakistan, Karachi, Pakistan subhash.chandir@ird.global.ORCID 0000-0002-6523-8875

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo estimate the prevalence of zero dose children (who have not received any dose of pentavalent (diphtheria, tetanus, pertussis, DESIGN AND

participantsWe conducted a descriptive analysis of child-level longitudinal immunisation records of 1 467 975 0-23 months children from the Sindh's Zindagi Mehfooz (Safe Life) Electronic Immunisation Registry (ZM-EIR), for the birth cohorts of 2017 and 2018.

settingSindh province, Pakistan which has a population of 47.9 million people and an annual birth cohort of 1.7 million. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome measure was zero dose status among enrolled children. Logistic regression was performed to identify the risk factors associated with the zero dose status.

resultsOut of 1 467 975 children enrolled in the ZM-EIR in Sindh, 10.6% (154 881/1 467 975) were zero dose. There were sharp inequities across the 27 districts. Zero dose children had a lower proportion of hospital births (28.5% vs 34.0%; difference 5.5 percentage points (pp) (95% CI 5.26 to 5.74); p<0.001) and higher prevalence from slums (49.5% vs 42.3%; difference 7.2 pp (95% CI 6.93 to 7.46); p<0.001), compared with non-zero dose children. Children residing in urban compared with rural areas were at a higher risk (relative risk (RR): 1.20; p<0.001; 95% CI 1.18 to 1.22), while children with educated compared with uneducated mothers were at a lower risk of being zero dose (RR: 0.47-0.96; p<0.001; 95% CI 0.45 to 0.98).

conclusionsDespite interacting with the immunisation system, 1 out of 10 children enrolled in the ZM-EIR in Sindh were zero dose. It is crucial to monitor the prevalence of zero dose children and investigate their characteristics and risk factors to effectively reach and follow-up with them.

Indexed as

Birth CohortImmunizationDiphtheria-Tetanus-Pertussis VaccineElectronicsHepatitis B VaccinesHumansInfantPakistanPrevalenceRegistriesVaccines, CombinedDiphtheria-Tetanus-Pertussis VaccineHepatitis B VaccinesVaccines, Combinedcommunity child healthpaediatric infectious disease & immunisationpublic health

Identifiers

PMID35584879
PMCPMC9119190

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.