Evidence map›Paper›PMID 35584850›Full record

ArticleBMJ open respiratory research2022

Harkiran K Kooner, Marrissa J McIntosh, Alexander M Matheson, Carmen Venegas, Nisarg Radadia, Terence Ho, Ehsan Ahmed Haider, Norman B Konyer, Giles E Santyr, Mitchell S Albert and 8 more

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in BMJ open respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 5 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02748798 early_phase1terminatednot on this map

Developing Optimal Parameters for Hyperpolarized Noble Gas (3He and 129Xe) and Inert Fluorinated Gas Magnetic Resonance Imaging of Lung Disorders

TypeinterventionalSponsorThunder Bay Regional Health Research InstituteRan2020 to 2021Enrolled10ConditionsLung Transplant, Lung Resection, Lung Cancer, AsthmaArmsHP 3He, HP 129Xe, PFP, SF6, 129Xe Small and Large Human Lung Coil
NCT05014516 terminatednot on this map

Lung Structure-Function In SurVivors of Mild and SEvere COVID-19 Infection: 129Xe MRI For Rapid Evaluation and NExt-wave Healthcare Planning

TypeobservationalSponsorThe Hospital for Sick ChildrenRan2021 to 2024Enrolled9ConditionsCOVID-19 Respiratory InfectionArms129Xenon gas
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Recovery of lung function during the first year after COVID-19: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. LongitudinalJournal of magnetic resonance imaging : JMRI · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Ventilation Defects atRadiology · 2023
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Harkiran K Kooner *Robarts Research Institute, Western University, London, Ontario, Canada.
Marrissa J McIntosh *Robarts Research Institute, Western University, London, Ontario, Canada.
Alexander M MathesonRobarts Research Institute, Western University, London, Ontario, Canada.
Carmen VenegasFirestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
Nisarg RadadiaDivision of Respirology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Terence HoFirestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
Ehsan Ahmed HaiderDepartment of Radiology, McMaster University, Hamilton, Ontario, Canada.
Norman B KonyerImaging Research Centre, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
Giles E SantyrThe Hospital for Sick Children, Toronto, Ontario, Canada.
Mitchell S AlbertDepartment of Chemistry, Lakehead University, Thunder Bay, Ontario, Canada.
Alexei OuriadovDepartment of Physics and Astronomy, Western University, London, Ontario, Canada.ORCID 0000-0002-0920-2528
Mohamed AbdelrazekDepartment of Medical Imaging, Western University, London, Ontario, Canada.
Miranda KirbyDepartment of Physics, Ryerson University, Toronto, Ontario, Canada.
Inderdeep DhaliwalDivision of Respirology, Department of Medicine, Western University, London, Ontario, Canada.
J Michael NicholsonDivision of Respirology, Department of Medicine, Western University, London, Ontario, Canada.ORCID 0000-0003-1560-7967
Parameswaran NairFirestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
Sarah SvenningsenFirestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
Grace ParragaRobarts Research Institute, Western University, London, Ontario, Canada gparraga@robarts.ca.ORCID 0000-0002-5619-4145
Western University · CASt. Joseph’s Healthcare Hamilton · CAMcMaster University · CAThunder Bay Regional Research Institute · CAToronto Metropolitan University · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients often report persistent symptoms beyond the acute infectious phase of COVID-19. Hyperpolarised

methodsConsenting participants with a confirmed diagnosis of PACS completed

resultsSeventy-six post-COVID and nine never-COVID participants were evaluated. Ventilation defect per cent (VDP) was abnormal and significantly greater in ever-COVID as compared with never-COVID participants (p<0.001) and significantly greater in ever-hospitalised compared with never-hospitalised participants who had COVID-19 (p=0.048), in whom diffusing capacity of the lung for carbon-monoxide (p=0.009) and 6-minute walk distance (6MWD) (p=0.005) were also significantly different.

conclusionTRIAL REGISTRATION NUMBER: NCT05014516.

Indexed as

COVID-19Respiration DisordersHumansMagnetic Resonance ImagingPost-Acute COVID-19 SyndromeRespiratory Function TestsXenon IsotopesXenon IsotopesCOVID-19Imaging/CT MRI etc

Identifiers

PMID35584850
PMCPMC9119175
OpenAlexW4280527757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.