Evidence map›Paper›PMID 35584822›Full record

ArticleClinical medicine (London, England)2022

Age modifies both the maximal temperature and inflammatory response in patients with SARS-CoV-2 infection.

Colin J Crooks, Joe West, Joanne R Morling, Mark Simmonds, Irene Juurlink, Steve Briggs, Simon Cruickshank, Susan Hammond-Pears, Dominick Shaw, Timothy R Card and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical medicine (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
  2. Article
  3. Doing what's necessary becomes doing what is possible.Clinical medicine (London, England) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Colin J CrooksNottingham Digestive Diseases Centre, Nottingham, UK, NIHR Nottingham Biomedical Research Centre, Nottingham, UK and Nottingham University Hospitals NHS Trust, Nottingham, UK.
Joe WestUniversity of Nottingham, Nottingham, UK, NIHR Nottingham Biomedical Research Centre, Nottingham, UK, Nottingham University Hospitals NHS Trust, Nottingham, UK and East Midlands Academic Health Science Network, Nottingham, UK.
Joanne R MorlingUniversity of Nottingham, Nottingham, UK, NIHR Nottingham Biomedical Research Centre, Nottingham, UK and Nottingham University Hospitals NHS Trust, Nottingham, UK.
Mark SimmondsNottingham University Hospitals NHS Trust, Nottingham, UK.
Irene JuurlinkNottingham University Hospitals NHS Trust, Nottingham, UK.
Steve BriggsNottingham University Hospitals NHS Trust, Nottingham, UK.
Simon CruickshankNottingham University Hospitals NHS Trust, Nottingham, UK.
Susan Hammond-PearsNottingham University Hospitals NHS Trust, Nottingham, UK and East Midlands Academic Health Science Network, Nottingham, UK.
Dominick ShawNIHR Nottingham Biomedical Research Centre, Nottingham, UK and Nottingham University Hospitals NHS Trust, Nottingham, UK.
Timothy R CardUniversity of Nottingham, Nottingham, UK, NIHR Nottingham Biomedical Research Centre, Nottingham, UK and Nottingham University Hospitals NHS Trust, Nottingham, UK.
Andrew FogartyUniversity of Nottingham, Nottingham, UK, NIHR Nottingham Biomedical Research Centre, Nottingham, UK and Nottingham University Hospitals NHS Trust, Nottingham, UK andrew.fogarty@nottingham.ac.uk.
Nottingham University Hospitals NHS Trust · GBNottingham Biomedical Research Centre · GBEast Midlands Academic Health Science Network · GBUniversity of Nottingham · GB

Funding

Medical Research Council MR/P008348/1
6 · The paper itself

Abstract

objectiveTo determine the maximal response of the temperature and inflammatory response to SARS-CoV-2 infection and how these are modified by age.

methodsParticipants were patients admitted to hospital with SARS-CoV-2 infection. For each participant, the maximal temperature and serum C-reactive protein (CRP) were identified and stratified by age. In a secondary analysis, these were compared in patients treated before and after dexamethasone.

resultsMean maximal temperature varied by age (p<0.001; ANOVA) with the highest mean maximal temperature of 37.3°C observed in patients aged 30-49 years and decreasing maximal mean temperatures in the older age groups, with the lowest measure of 36.8°C observed in individuals aged 90-99 years. The mean maximal serum CRP also varied across age groups (p<0.001; ANOVA) and increased with age across all age categories from 34.5 mg/dL (95% confidence interval (CI) 22.0-47.0) for individuals aged 20-29 years to 77.6 mg/dL (95% CI 72.0-83.2) in those aged 80-89 years. After dexamethasone became standard treatment for COVID-19 pneumonia, mean maximal CRP decreased by 17 mg/dL (95% CI -22 to -11).

conclusionAge modifies both maximal temperature and systemic inflammatory response in patients with SARS-CoV-2 infection.

Indexed as

COVID-19AgedC-Reactive ProteinDexamethasoneHospitalizationHumansSARS-CoV-2TemperatureC-Reactive ProteinDexamethasoneageCOVID-19infectioninflammationtemperature

Identifiers

PMID35584822
PMCPMC9135072
OpenAlexW4280554770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.