Evidence map›Paper›PMID 35584681›Full record

ArticleCell reports2022

Loss of T cell tolerance in the skin following immunopathology is linked to failed restoration of the dermal niche by recruited macrophages.

Heather C West, James Davies, Stephen Henderson, Oluyori K Adegun, Sophie Ward, Ivana R Ferrer, Chanidapa A Tye, Andres F Vallejo, Laura Jardine, Matthew Collin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Heather C WestDepartment of Haematology, University College London (UCL) Cancer Institute, London WC1E 6DD, UK; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London NW3 2PF, UK.
James DaviesDepartment of Haematology, University College London (UCL) Cancer Institute, London WC1E 6DD, UK; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London NW3 2PF, UK.
Stephen HendersonBill Lyons Informatics Centre, Cancer Institute, University College London, London WC1E 6DD, UK.
Oluyori K AdegunDepartment of Cellular Pathology, University College London Hospitals NHS Foundation Trust, London, UK.
Sophie WardDepartment of Haematology, University College London (UCL) Cancer Institute, London WC1E 6DD, UK; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London NW3 2PF, UK.
Ivana R FerrerDepartment of Haematology, University College London (UCL) Cancer Institute, London WC1E 6DD, UK; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London NW3 2PF, UK.
Chanidapa A TyeDepartment of Haematology, University College London (UCL) Cancer Institute, London WC1E 6DD, UK; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London NW3 2PF, UK.
Andres F VallejoClinical and Experimental Sciences (Sir Henry Wellcome Laboratories, Faculty of Medicine) and Institute for Life Sciences, University of Southampton, Southampton, UK.
Laura JardineBiosciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Matthew CollinNewcastle University Translational and Clinical Research Institute and NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle Upon Tyne, UK.
Marta E PolakClinical and Experimental Sciences (Sir Henry Wellcome Laboratories, Faculty of Medicine) and Institute for Life Sciences, University of Southampton, Southampton, UK.
Clare L BennettDepartment of Haematology, University College London (UCL) Cancer Institute, London WC1E 6DD, UK; Institute for Immunity and Transplantation, Division of Infection and Immunity, University College London, London NW3 2PF, UK. Electronic address: c.bennett@ucl.ac.uk.
Institute of Infection and Immunity · CAUniversity College London · GBUniversity of Southampton · GBNewcastle University · GBNIHR Newcastle Biomedical Research Centre · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L001608/1Biotechnology and Biological Sciences Research Council BB/T005246/1Medical Research Council 1450227Wellcome TrustWellcome Trust 109377/Z/15/ZWellcome Trust WT097941
6 · The paper itself

Abstract

T cell pathology in the skin leads to monocyte influx, but we have little understanding of the fate of recruited cells within the diseased niche, or the long-term impact on cutaneous immune homeostasis. By combining a murine model of acute graft-versus-host disease (aGVHD) with analysis of patient samples, we demonstrate that pathology initiates dermis-specific macrophage differentiation and show that aGVHD-primed macrophages continue to dominate the dermal compartment at the relative expense of quiescent MHCII

Indexed as

Graft vs Host DiseaseSkinAnimalsHumansImmune ToleranceMacrophagesMiceMonocytesT-Lymphocytes, Regulatorycontact hypersensitivityCP: immunologydermisdisease nichegraft-versus-host diseasemacrophagesmonocytesregulatory T cellsskintolerance

Identifiers

PMID35584681
PMCPMC9620741
OpenAlexW4280489892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.