ArticleCell reports2022
Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Candidalysin promotes fungal-specific Th17 CD4 T cell differentiation and protective systemic immunogenicity.Mucosal immunology · 2026Article
- AbioRxiv : the preprint server for biology · 2026Article
- An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans.Nature communications · 2026Article
- Article
- Ume6 protein complexes connect morphogenesis, adherence and hypoxic genes to shape Candida albicans biofilm architecture.Nature microbiology · 2025Article
- Article
- Fucoidan as a therapeutic agent for ulcerative colitis: mechanisms of action and modulation of the gut microbiota.Frontiers in cellular and infection microbiology · 2025Review
- ControllingInfection and immunity · 2024Review
- Candida-bacterial cross-kingdom interactions.Trends in microbiology · 2023Review
- Commensal fungi in intestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2023Review
- Interplay between host and Candida albicans during commensal gut colonization.PLoS pathogens · 2023Article
- Candida albicans exploits N-acetylglucosamine as a gut signal to establish the balance between commensalism and pathogenesis.Nature communications · 2023Article
- Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization.Science immunology · 2023Article
- Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity.The Journal of clinical investigation · 2023Article
- Review
- The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition ofCurrent clinical microbiology reports · 2023Review
- Intestinal fungi and antifungal secretory immunoglobulin A in Crohn's disease.Frontiers in immunology · 2023Review
- Molecular association ofFrontiers in cellular and infection microbiology · 2023Review
- Targeting Th17 cells: a promising strategy to treat oral mucosal inflammatory diseases.Frontiers in immunology · 2023Review
- Into the wild: How exposure to wild or domesticated fungi shapes immune responses in mice.PLoS pathogens · 2022Article
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Authors and funding
11 authors.
Funding
Abstract
Systemic immunity is stringently regulated by commensal intestinal microbes, including the pathobiont Candida albicans. This fungus utilizes various transcriptional and morphological programs for host adaptation, but how this heterogeneity affects immunogenicity remains uncertain. We show that UME6, a transcriptional regulator of filamentation, is essential for intestinal C. albicans-primed systemic Th17 immunity. UME6 deletion and constitutive overexpression strains are non-immunogenic during commensal colonization, whereas immunogenicity is restored by C. albicans undergoing oscillating UME6 expression linked with β-glucan and mannan production. In turn, intestinal reconstitution with these fungal cell wall components restores protective Th17 immunity to mice colonized with UME6-locked variants. These fungal cell wall ligands and commensal C. albicans stimulate Th17 immunity through multiple host pattern recognition receptors, including Toll-like receptor 2 (TLR2), TLR4, Dectin-1, and Dectin-2, which work synergistically for colonization-induced protection. Thus, dynamic gene expression fluctuations by C. albicans during symbiotic colonization are essential for priming host immunity against disseminated infection.
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