ArticleCell reports. Medicine2022
Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function.
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Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
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- Davanat-Mimetic Galactomannan and Its Sulfated Derivative: Structure and Antitumor Effects against Melanoma.Biomacromolecules · 2025Article
- Laser-capture microdissection for spatial transcriptomics of immunohistochemically detected neurons.The Journal of biological chemistry · 2025Article
- Macrophage diversity in cancer dissemination and metastasis.Cellular & molecular immunology · 2024Review
- Computational immune synapse analysis reveals T-cell interactions in distinct tumor microenvironments.Communications biology · 2024Article
- Innate Immune Cells in Melanoma: Implications for Immunotherapy.International journal of molecular sciences · 2024Review
- Tumor associated macrophages as key contributors and targets in current and future therapies for melanoma.Expert review of clinical immunology · 2024Review
- Integrating AI-Powered Digital Pathology and Imaging Mass Cytometry Identifies Key Classifiers of Tumor Cells, Stroma, and Immune Cells in Non-Small Cell Lung Cancer.Cancer research · 2024Article
- Macrophages in inflammatory skin diseases and skin tumors.Frontiers in immunology · 2024Review
- Nitidine chloride regulates cell function of bladder cancer in vitro through downregulating Lymphocyte antigen 75.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment.Journal for immunotherapy of cancer · 2023Article
- Functionally and Metabolically Divergent Melanoma-Associated Macrophages Originate from Common Bone-Marrow Precursors.Cancers · 2023Article
- Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancers.Clinical epigenetics · 2023Article
- Dendritic Cell Subsets in Melanoma: Pathophysiology, Clinical Prognosis and Therapeutic Exploitation.Cancers · 2023Review
- High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis.Cancer immunology research · 2023Article
- Functional states of myeloid cells in cancer.Cancer cell · 2023Review
- HEV-associated dendritic cells are observed in metastatic tumor-draining lymph nodes of cutaneous melanoma patients with longer distant metastasis-free survival after adjuvant immunotherapy.Frontiers in immunology · 2023Article
- Impaired function of dendritic cells within the tumor microenvironment.Frontiers in immunology · 2023Review
- A topology perspective on macrophages in melanoma metastasis.Cell reports. Medicine · 2022Article
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Authors and funding
18 authors at 3 institutions in 1 country.
Jan MartinekThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Jianan LinThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Kyung In KimThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Victor G WangThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA.
Te-Chia WuThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Michael ChiorazziDepartment of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, CT, USA.
Hannah BoruchovThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Ananya GulatiThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Shamreethaa SeenirajThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Lili SunThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Florentina MarchesThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Paul RobsonThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA.
Anthony RongvauxFred Hutchinson Cancer Research Center, Program in Immunology, Seattle, WA, USA.
Richard A FlavellDepartment of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, CT, USA.
Joshy GeorgeThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Jeffrey H ChuangThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Jacques BanchereauThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Karolina PaluckaThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT, USA. Electronic address: karolina.palucka@jax.org.
Jackson Laboratory · USHoward Hughes Medical Institute · USFred Hutch Cancer Center · US
Funding
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Mark D ADAMS · 1985 to 2026
$61.9M(PQ3) Cellular and Molecular Mechanisms Driving Myeloid Compartment Variation in Human Triple Negative Breast CancerR01CA219880 · NCI · JACKSON LABORATORY · PI PALUCKA, ANNA KAROLINA · 2017 to 2021
$3.4MQuantitative Computational Methods to Accurately Measure Tumor Heterogeneity in Solid Tumors to Inform Development of Evolution-based Treatment StrategiesR01CA230031 · NCI · JACKSON LABORATORY · PI CHUANG, JEFFREY HSU-MIN · 2018 to 2022
$2.6MTowards True Precision Oncology: Validation of a Comprehensively Humanized, Autologous Mouse ModelR01CA204115 · NCI · WASHINGTON UNIVERSITY · PI FIELDS, RYAN C, FLAVELL, RICHARD A · 2017 to 2019
$1.8MHumanized mouse models to dissect in vivo the interplay between melanoma and the immune systemR01CA195712 · NCI · JACKSON LABORATORY · PI FLAVELL, RICHARD A, PALUCKA, ANNA KAROLINA · 2015 to 2017
$1.3MAutologous Humanized Mouse Model of Non-Small Cell Lung Cancer (NSCLC) to Investigate the Tumor-Immune Landscape and Its Response to TreatmentK08CA245211 · NCI · YALE UNIVERSITY · PI CHIORAZZI, MICHAEL · 2019 to 2023
$741kNCI NIH HHS K08 CA245211NCI NIH HHS P30 CA034196NCI NIH HHS R01 CA195712NCI NIH HHS R01 CA204115NCI NIH HHS R01 CA219880NCI NIH HHS R01 CA230031
Abstract
Modulation of immune function at the tumor site could improve patient outcomes. Here, we analyze patient samples of metastatic melanoma, a tumor responsive to T cell-based therapies, and find that tumor-infiltrating T cells are primarily juxtaposed to CD14
Indexed as
MelanomaNeoplasms, Second PrimarySkin NeoplasmsHumansMacrophagesPhenotypeT-LymphocytesCD205DEC-205dendritic cellsLY75macrophagemelanomamyeloid infiltratespatial analysisspatial tissue organizationtranscriptomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.