ArticleObesity facts2022
Predicted Fat Mass, Lean Body Mass, and Risk of Hypertension: Results from a Chinese Male Cohort Study.
Article in Obesity facts, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 12 citations in OpenAlex.
- Lean body mass index and the risk of diabetes onset: A nationwide epidemiological cohort study.Journal of diabetes investigation · 2025Article
- The lean body mass to visceral fat mass ratio is negatively associated with cardiometabolic disorders: a cross-sectional study.Scientific reports · 2025Article
- Association of 24 Conventional and Unconventional Anthropometric Indicators with Pre-Hypertension or Hypertension: A Population-Based Cross-Sectional Study in Chinese Population.Vascular health and risk management · 2025Article
- Effects of serum HIF-1α, VEGF, and uPA levels on clinicopathologic findings and prognosis in oral squamous cell carcinoma.International journal of clinical and experimental pathology · 2025Article
- Dose-response relationship between body mass index and hypertension: A cross-sectional study from Eastern China.Preventive medicine reports · 2024Article
- The relationship between anthropometric indices and the presence of hypertension in an Iranian population sample using data mining algorithms.Journal of human hypertension · 2024Article
- Association of organ damage with predicted fat mass in a community-dwelling elderly: the Northern Shanghai study.Aging clinical and experimental research · 2024Article
- Muscle quality is negatively related to hypertension prevalence in adults: Results from NHANES 2011-2014.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- The association of body composition and fat distribution with hypertension in community-dwelling older adults: the Bushehr Elderly Health (BEH) program.BMC public health · 2023Article
- Association between lean body mass and hypertension: A cross-sectional study of 50 159 NHANES participants.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- The role of predicted lean body mass and fat mass in non-alcoholic fatty liver disease in both sexes: Results from a secondary analysis of the NAGALA study.Frontiers in nutrition · 2023Article
- Association of predicted fat mass and lean body mass with diabetes: a longitudinal cohort study in an Asian population.Frontiers in nutrition · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionFew studies have deciphered whether lean body mass (LBM) or fat mass (FM) is predominantly responsible for the body mass index (BMI)-hypertension association. This study aimed to assess the associations of predicted LBM and FM with hypertension risk among Chinese male adults.
methodsA prospective cohort study was conducted among 2,812 male participants free of hypertension in the Fangchenggang Area Males Health and Examination Survey in 2009. We performed multivariable Cox models and restricted cubic spline to examine the associations of predicted LBM and FM and BMI with hypertension, and to further explore the mediating roles of lipid and glycemic traits in the relationship between predicted FM and blood pressure.
resultsOf 1,238 participants included in the cohort study, 306 (24.8%) hypertension cases were identified during a median follow-up of 3.8 years, with an incidence rate of 7.0 per 100 person-years. A positive linear-shaped association was consistently observed between BMI and hypertension (p for trend <0.001). Multivariable-adjusted Cox models including predicted LBM and FM observed a positive association between predicted FM and hypertension. Compared with those in the lowest quartile of predicted FM, men in the highest quartile had a hazard ratio (HR) of 1.83 (95% confidence interval (CI): 1.13-2.97) for hypertension. The HR per standard deviation increase of BMI and predicted FM was 1.11 (95% CI: 1.04-1.19) above 23.1 kg/m2 and 1.05 (95% CI: 1.02-1.15) above 14.6 kg, respectively. However, predicted LBM was not associated with hypertension. In addition, high-density lipoprotein cholesterol (HDL-c) and fasting blood glucose (FBG) mediated the relationship of predicted FM with systolic blood pressure, with a mediation ratio of 37.1% and 8.2%, respectively. Furthermore, total cholesterol (TC) and triglyceride (TG) positively mediated the association of predicted FM with diastolic blood pressure, with a mediation ratio of 9.5% and 9.9%, respectively.
conclusionHigher predicted FM might play a central role in the positive linear relationship of the BMI-hypertension association in Chinese male adults, and the link from predicted FM to blood pressure was partially mediated by TC, TG, HDL-c, and FBG.
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