ReviewAnesthesia and analgesia2022
Perioperative Brain Health in the Older Adult: A Patient Safety Imperative.
Review in Anesthesia and analgesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 43 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perioperative Use of Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery: a 2×2 Factorial Trial
Long-term Follow-up of Perioperative Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery
Impact of Perioperative Transcranial Photobiomodulation on Delayed Neurocognitive Recovery in Older Patients After Surgery: a Randomized, Double-blind, Pseudo-modulation-controlled Preliminary Clinical Trial
Who cites it
43 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Cognitive Impairment and Postoperative Outcomes in Patients Undergoing Primary Total Hip Arthroplasty and Primary Total Knee Arthroplasty: A Systematic Review and Meta-analysis.Annals of African medicine · 2026Pooled it
- Psychological factors associated with postoperative cognitive outcomes in older adults: a systematic review and meta-analysis.British journal of anaesthesia · 2026Pooled it
- Esketamine for negative emotions and cognitive function in general anesthesia: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- The effect of neuromuscular blocking reversal agents on perioperative neurocognitive function after general anaesthesia: a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Cognitive prehabilitation for older adults undergoing elective surgery: a systematic review and narrative synthesis.Frontiers in aging neuroscience · 2024Pooled it
- Electroencephalographic guided propofol-remifentanil TCI anesthesia with and without dexmedetomidine in a geriatric population: electroencephalographic signatures and clinical evaluation.Journal of clinical monitoring and computing · 2024Trial
- Promoting brain health in older surgical patients: A pre-post evaluation of an educational module.Journal of anesthesia and translational medicine · 2026Article
- Brain health awareness among solid organ transplant candidates and recipients: a single centre survey.BMC neurology · 2026Article
- Comparison of functional disability in older surgical patients with and without probable cognitive impairment: A longitudinal prospective cohort study.Journal of anesthesia and translational medicine · 2026Article
- Postoperative delirium: from bundles to precision prevention.Anesthesia and pain medicine · 2026Review
- Genetic and epigenetic insights into perioperative neurocognitive disorders: a narrative review.British journal of anaesthesia · 2026Review
- Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.British journal of anaesthesia · 2026Article
- Perioperative Best Practices and Delirium in Patients With Cognitive Impairment.JAMA network open · 2026Observational
- Characterizing preoperative domain-specific performance on the Montreal Cognitive Assessment and exploring its associations with adverse outcomes.Anesthesiology and perioperative science · 2026Article
- Perioperative dynamic EEG patterns correlated with changes in cognitive subdomains.Clinical neurophysiology practice · 2026Article
- Total intravenous anesthesia facilitates early cognitive recovery compared with inhalational anesthesia in Alzheimer's disease patients after cervical lymphatic-venous anastomosis: a randomized controlled trial.American journal of translational research · 2026Article
- Anesthesia medication management competency in the post-anesthesia care unit: current challenges and strategies for enhancement-a qualitative study of nurses' experiences.Frontiers in medicine · 2026Article
- Association Between Preoperative Activities of Daily Living and Postoperative Delirium in Elderly Patients Undergoing Non-Cardiac Surgery: A Prospective Cohort Study.Clinical interventions in aging · 2026Article
- Preoperative electroacupuncture for prevention of postoperative delirium in older adults undergoing total knee arthroplasty: protocol for a multicenter randomized controlled trial.Annals of medicine · 2025Article
- Post-Operative Delirium in Elderly Patients: A Narrative Review.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
While people 65 years of age and older represent 16% of the population in the United States, they account for >40% of surgical procedures performed each year. Maintaining brain health after anesthesia and surgery is not only important to our patients, but it is also an increasingly important patient safety imperative for the specialty of anesthesiology. Aging is a complex process that diminishes the reserve of every organ system and often results in a patient who is vulnerable to the stress of surgery. The brain is no exception, and many older patients present with preoperative cognitive impairment that is undiagnosed. As we age, a number of changes occur in the human brain, resulting in a patient who is less resilient to perioperative stress, making older adults more susceptible to the phenotypic expression of perioperative neurocognitive disorders. This review summarizes the current scientific and clinical understanding of perioperative neurocognitive disorders and recommends patient-centered, age-focused interventions that can better mitigate risk, prevent harm, and improve outcomes for our patients. Finally, it discusses the emerging topic of sleep and cognitive health and other future frontiers of scientific inquiry that might inform clinical best practices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.