ReviewNursing research
A Concept Development for the Symptom Science Model 2.0.
Review in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Peripheral Neuropathy Instruments for Individuals with Cancer: A COSMIN-Based Systematic Review of Measurement Properties.Current oncology (Toronto, Ont.) · 2024Pooled it
- Systematic review: Individual-level factors and social determinants of health impacting sleep health in individuals with inflammatory bowel disease.Journal of advanced nursing · 2023Pooled it
- Identification of Symptom Profiles in Prostate Cancer Survivors.Oncology nursing forum · 2025Trial
- Social determinants of health as predictors of latent symptom clusters in patients undergoing maintenance hemodialysis: A secondary analysis of the HOPE consortium randomized trial.The journal of pain · 2026Article
- Article
- Article
- Understanding symptoms in the lives of adult patients with acute or chronic illness: a phenomenological study of patient experiences.International journal of qualitative studies on health and well-being · 2025Article
- Biomarkers associated with cancer-related anorexia in lung cancer: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Differences in symptom clusters based on multidimensional symptom experience and symptom burden in stroke patients.Scientific reports · 2025Article
- Psychoneurological symptom clusters in patients with first stroke and relationship with inflammatory markers: a latent profile analysis.Frontiers in psychology · 2025Article
- Core Outcomes of Self-Care Behaviours in Patients with Breast Cancer Treated with Oral Anticancer Agents: A Systematic Review.Cancers · 2024Review
- The Gut Microbiome and Symptom Burden After Kidney Transplantation: An Overview and Research Opportunities.Biological research for nursing · 2024Review
- Development and validation of the perceived symptom manageability scale among people living with the human immunodeficiency virus.BMC psychology · 2024Article
- Pain and Heart Failure During Transport by Emergency Medical Services and Its Associated Outcomes: Hospitalization, Mortality, and Length of Stay.Western journal of nursing research · 2024Article
- Epigenomic Links Between Social Determinants of Health and Symptoms: A Scoping Review.Biological research for nursing · 2023Article
- Subacute and Chronic Spinal Cord Injury: A Scoping Review of Epigenetics and Secondary Health Conditions.Epigenetics insights · 2023Article
- A framework for symptom self-management for individuals with complex health conditions.Nursing outlookArticle
- Inflammatory Markers and Fatigue in Individuals With Moderate to Severe Chronic Obstructive Pulmonary Disease.Nursing researchArticle
- Capturing the human impact of living with multiple long-term conditions in routine electronic health records - lost in translation?Journal of multimorbidity and comorbidityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe National Institute of Nursing Research developed the National Institutes of Health symptom science model (SSM) in 2015 as a parsimonious conceptual model to guide symptom science research.
objectivesThis concept development paper synthesizes justifications to strengthen the original model.
methodsA literature review was performed, discussions with symptom science content expert stakeholders were held, and opportunities for expanding the current model were identified. Concept elements for a revised conceptual model-the SSM 2.0-were developed.
resultsIn addition to the four original concept elements (complex symptom presentation, phenotypic characterization, biobehavioral factors [previously biomarker discovery], and clinical applications), three new concept elements are proposed, including social determinants of health, patient-centered experience, and policy/population health. DISCUSSION: There have been several calls to revise the original SSM from the nursing scientific community to expand its utility to other healthcare settings. Incorporating three additional concept elements can facilitate a broader variety of translational nursing research symptom science collaborations and applications, support additional scientific domains for symptom science activities, and produce more translatable symptom science to a wider audience of nursing research scholars and stakeholders during recovery from the COVID-19 pandemic. The revised SSM 2.0 with newly incorporated social determinants of health, patient-centered experience, and policy/population health components now empowers nursing scientists and scholars to address specific symptom science public health challenges particularly faced by vulnerable and underserved populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.