Evidence map›Paper›PMID 35584148›Full record

ArticlePloS one2022

Hispanic ethnicity and mortality among critically ill patients with COVID-19.

Ana C Ricardo, Jinsong Chen, Stephanie M Toth-Manikowski, Natalie Meza, Min Joo, Shruti Gupta, Deepa G Lazarous, David E Leaf, James P Lash, STOP-COVID Investigators

Registry-linked trialAbstract readMulticenter Study
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04343898 (Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04343898 completednot on this map

Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19

TypeobservationalSponsorBrigham and Women's HospitalRan2020 to 2023Enrolled5,154ConditionsCoronavirus InfectionArmsNo intervention
3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana C RicardoDepartment of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, IL, United States of America.ORCID 0000-0001-8670-3644
Jinsong ChenDepartment of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, IL, United States of America.
Stephanie M Toth-ManikowskiDepartment of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, IL, United States of America.ORCID 0000-0001-9635-7554
Natalie MezaDepartment of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, IL, United States of America.
Min JooDepartment of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, IL, United States of America.
Shruti GuptaDepartment of Medicine, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, United States of America.ORCID 0000-0002-5747-2151
Deepa G LazarousDepartment of Pulmonary Critical Care and Sleep Medicine, Georgetown University Hospital, Washington, DC, United States of America.
David E LeafDepartment of Medicine, Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, United States of America.ORCID 0000-0001-7875-090X
James P LashDepartment of Medicine, Division of Nephrology, University of Illinois at Chicago, Chicago, IL, United States of America.ORCID 0000-0002-6580-4080
STOP-COVID Investigators

Funding

Hispanic Chronic Renal Insufficiency Cohort(CRIC) StudyR01DK072231 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LASH, JAMES P. · 2005 to 2021
$10.9M
Deferoxamine for the Prevention of Acute Kidney InjuryR01DK125786 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2020 to 2024
$3.5M
Sleep-Disordered Breathing and Outcomes in Chronic Kidney DiseaseR01DK118736 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RICARDO, ANA CATHERINE · 2019 to 2023
$2.9M
COVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Health Disparities in Chronic Kidney Disease Mentoring ProgramK24DK092290 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LASH, JAMES P. · 2012 to 2022
$1.9M
Precision Medicine Approach to Vitamin D3 Administration in Critical IllnessR01HL144566 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2019 to 2022
$1.8M
Novel Pathways and Therapeutic Targets for Cisplatin-Associated Acute Kidney InjuryK23DK125672 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Shruti Gupta · 2022 to 2026
$998k
Diet Related Inflammation and Kidney Function Decline in Racial/Ethnic MinoritiesK23DK124644 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI JOHNS, TANYA · 2021 to 2023
$752k
NHLBI NIH HHS R01 HL144566NIDDK NIH HHS K23 DK125672NIDDK NIH HHS K24 DK092290NIDDK NIH HHS R01 DK072231NIDDK NIH HHS R01 DK118736NIDDK NIH HHS R01 DK125786
6 · The paper itself

Abstract

backgroundHispanic persons living in the United States (U.S.) are at higher risk of infection and death from coronavirus disease 2019 (COVID-19) compared with non-Hispanic persons. Whether this disparity exists among critically ill patients with COVID-19 is unknown.

objectiveTo evaluate ethnic disparities in mortality among critically ill adults with COVID-19 enrolled in the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID).

methodsMulticenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units (ICU) at 67 U.S. hospitals from March 4 to May 9, 2020. Multilevel logistic regression was used to evaluate 28-day mortality across racial/ethnic groups.

resultsA total of 2153 patients were included (994 [46.2%] Hispanic and 1159 [53.8%] non-Hispanic White). The median (IQR) age was 62 (51-71) years (non-Hispanic White, 66 [57-74] years; Hispanic, 56 [46-67] years), and 1462 (67.9%) were men. Compared with non-Hispanic White patients, Hispanic patients were younger; were less likely to have hypertension, chronic obstructive pulmonary disease, coronary artery disease, or heart failure; and had longer duration of symptoms prior to ICU admission. During median (IQR) follow-up of 14 (7-24) days, 785 patients (36.5%) died. In analyses adjusted for age, sex, clinical characteristics, and hospital size, Hispanic patients had higher odds of death compared with non-Hispanic White patients (OR, 1.44; 95% CI, 1.12-1.84).

conclusionsAmong critically ill adults with COVID-19, Hispanic patients were more likely to die than non-Hispanic White patients, even though they were younger and had lower comorbidity burden. This finding highlights the need to provide earlier access to care to Hispanic individuals with COVID-19, especially given our finding of longer duration of symptoms prior to ICU admission among Hispanic patients. In addition, there is a critical need to address ongoing disparities in post hospital discharge care for patients with COVID-19.

Indexed as

COVID-19AdultAgedCohort StudiesCritical IllnessEthnicityFemaleHospital MortalityHumansIntensive Care UnitsMaleMiddle AgedSARS-CoV-2United States

Identifiers

PMID35584148
PMCPMC9116663

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.