ArticleIEEE transactions on medical imaging2022
Positronium Lifetime Image Reconstruction for TOF PET.
Article in IEEE transactions on medical imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- First ex-vivo positronium imaging of tissues with modular J-PET scanner usingZeitschrift fur medizinische Physik · 2026Article
- First positronium lifetime imaging usingScientific reports · 2026Article
- GATE 10 Monte Carlo particle transport simulation: I. Development and new features.Physics in medicine and biology · 2026Article
- High-Resolution Positronium Lifetime Tomography at Clinical Activity Levels on the PennPET Explorer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Phantom imaging demonstration of positronium lifetime with a long axial field-of-view PET/CT andEJNMMI physics · 2025Article
- Realistic total-body J-PET geometry optimization: Monte Carlo study.Medical physics · 2025Article
- A statistical reconstruction algorithm for positronium lifetime imaging using time-of-flight positron emission tomography.IEEE transactions on radiation and plasma medical sciences · 2025Article
- Fast high-resolution lifetime image reconstruction for positron lifetime tomography.Communications physics · 2025Article
- First positronium lifetime imaging with scandium-44 on a long axial field-of-view PET/CT.Frontiers in nuclear medicine · 2025Article
- High-resolution positronium lifetime tomography by the method of moments.Physics in medicine and biology · 2024Article
- Positronium image of the human brain in vivo.Science advances · 2024Article
- Ortho-positronium lifetime for soft-tissue classification.Scientific reports · 2024Article
- Positronium lifetime validation measurements using a long-axial field-of-view positron emission tomography scanner.EJNMMI physics · 2024Article
- SPLIT: Statistical Positronium Lifetime Image Reconstruction via Time-Thresholding.IEEE transactions on medical imaging · 2024Article
- Enhanced positronium lifetime imaging through two-component reconstruction in time-of-flight positron emission tomography.Frontiers in physics · 2024Article
- Developing a novel positronium biomarker for cardiac myxoma imaging.EJNMMI physics · 2023Article
- The properties of the positronium lifetime image reconstruction based on maximum likelihood estimation.Bio-algorithms and med-systems · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Positron emission tomography is widely used in clinical and preclinical applications. Positronium lifetime carries information about the tissue microenvironment where positrons are emitted, but such information has not been captured because of two technical challenges. One challenge is the low sensitivity in detecting triple coincidence events. This problem has been mitigated by the recent developments of PET scanners with long (1-2 m) axial field of view. The other challenge is the low spatial resolution of the positronium lifetime images formed by existing methods that is determined by the time-of-flight (TOF) resolution (200-500 ps) of existing PET scanners. This paper solves the second challenge by developing a new image reconstruction method to generate high-resolution positronium lifetime images using existing TOF PET. Simulation studies demonstrate that the proposed method can reconstruct positronium lifetime images at much better spatial resolution than the limit set by the TOF resolution of the PET scanner. The proposed method opens up the possibility of performing positronium lifetime imaging using existing TOF PET scanners. The lifetime information can be used to understand the tissue microenvironment in vivo which could facilitate the study of disease mechanism and selection of proper treatments.
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