ArticleJournal of neurophysiology2022
Human
Open access · greenAbstract read
In one paragraph
Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Comparative analysis of 105 datasets across species and tissues reveals differential transcriptomic responses to cannabinoids THC and CBD.Journal of cannabis research · 2025Article
- Electrophysiological Abnormalities and Pharmacological Corrections of Pathogenic Missense Variants in KCNQ3.Neuroscience bulletin · 2025Article
- Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Integrative analysis of KCNQ1 variants reveals molecular mechanisms of type 1 long QT syndrome pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Migraine is a dysfunction of neuronal potassium ion channels.Frontiers in neurology · 2025Review
- Editorial: Pathogenic potassium channel variants in neurological disorders: from functional analysis to personalized pharmacological approaches.Frontiers in cellular neuroscience · 2025Article
- Review
- The mitochondrial calcium uniporter inhibitor Ru265 increases neuronal excitability and reduces neurotransmission via off-target effects.British journal of pharmacology · 2024Article
- Selective KCNQ2/3 Potassium Channel Opener ICA-069673 Inhibits Excitability in Mouse Vagal Sensory Neurons.The Journal of pharmacology and experimental therapeutics · 2024Article
- Phox2b-expressing neurons contribute to breathing problems in Kcnq2 loss- and gain-of-function encephalopathy models.Nature communications · 2023Article
- Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Clinically RelevantInternational journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 11 institutions in 2 countries.
Aguan D WeiCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0003-2596-9240
Paul WakenightCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Theresa A ZwingmanCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0001-8798-7386
Angela M BardCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Nikhil SahaiCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Marjolein H WillemsenDepartment of Human Genetics and Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Helenius J SchelhaasDepartment of Neurology, Academic Centre for Epileptology Kempenhaeghe, Heeze, The Netherlands.
Alexander P A StegmannDepartment of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands.ORCID 0000-0002-9736-7137
Judith S VerhoevenDepartment of Neurology, Academic Centre for Epileptology Kempenhaeghe, Heeze, The Netherlands.
Stella A de ManDepartment of Pediatrics, Amphia Hospital, Breda, The Netherlands.ORCID 0000-0002-3895-4649
Marja W WesselsDepartment of Human Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands.
Tjitske KleefstraDepartment of Human Genetics and Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-0956-0237
Deepali N ShindeAmbry Genetics, Aliso Viejo, California.
Katherine L HelbigAmbry Genetics, Aliso Viejo, California.ORCID 0000-0001-8249-0549
Alice BasingerMedical Genetics, Cook Children's Hospital, Fort Worth, Texas.
Victoria F WagnerDepartment of Pediatrics, University of Texas Health Science Center, Houston, Texas.
David Rodriguez-BuriticaDepartment of Pediatrics, University of Texas Health Science Center, Houston, Texas.
Emily BryantDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
John J MillichapDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Kathleen J MillenCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
William B DobynsCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Jan-Marino RamirezCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.
Franck K KalumeCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington.ORCID 0000-0002-5528-2565
University of Washington · USKempenhaeghe · NLNorthwestern University · USRadboud University Nijmegen · NLThe University of Texas Health Science Center at Houston · USAmbry Genetics (United States) · USAmphia Ziekenhuis · NLChildren's Hospital of Philadelphia · USCook Children's Medical Center · USErasmus University Rotterdam · NLMaastricht University Medical Centre · NL
Funding
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9MUnraveling respiratory rhythm generation in the medullary networkR01HL126523 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI Jan M. Ramirez · 2015 to 2026
$8.3MMegalencephaly and segmental brain overgrowth in humansR01NS092772 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI MILLEN, KATHLEEN JOYCE · 2015 to 2019
$3.3MPathological Mechanisms of Human Cerebeller MalformationsR01NS095733 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI MILLEN, KATHLEEN JOYCE · 2016 to 2020
$3.0MMouse models of Pik3ca brain overgrowth disordersR01NS099027 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI MILLEN, KATHLEEN JOYCE · 2017 to 2021
$3.0MMechanisms of epilepsy-related death in Leigh syndromeR01NS102796 · NINDS · SEATTLE CHILDREN'S HOSPITAL · PI KALUME, FRANCK K · 2017 to 2021
$2.1MNHLBI NIH HHS R01 HL126523NICHD NIH HHS P50 HD103524NINDS NIH HHS R01 NS092772NINDS NIH HHS R01 NS095733NINDS NIH HHS R01 NS099027NINDS NIH HHS R01 NS102796
Abstract
We identified six novel de novo human
Indexed as
EpilepsyIntellectual DisabilityAnimalsChildCricetinaeCricetulusHEK293 CellsHumansKCNQ Potassium ChannelsMiceMutation, MissenseSeizuresKCNQ5 protein, humanKCNQ Potassium Channelschannelopathyepilepsyintellectual disabilityKCNQ5M current
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.