Evidence map›Paper›PMID 35583969›Full record

ArticleChembiochem : a European journal of chemical biology2022

Genetic Survey of Psilocybe Natural Products.

Sebastian Dörner, Kai Rogge, Janis Fricke, Tim Schäfer, Jacob M Wurlitzer, Markus Gressler, Duyen N K Pham, David R Manke, Andrew R Chadeayne, Dirk Hoffmeister

Open access · hybridAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Clade III Synthases Add Cyclic and Linear Terpenoids to the Psilocybe Metabolome.Chembiochem : a European journal of chemical biology · 2025
    Article
  7. Chemical Composition and Biological Activities ofPharmaceuticals (Basel, Switzerland) · 2025
    Review
  8. Review
  9. Article
  10. ExploringJournal of fungi (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Cultivation, chemistry, and genome ofJournal of psychedelic studies · 2024
    Article
  16. Methyl transfer in psilocybin biosynthesis.Nature communications · 2024
    Article
  17. Phylogenomics of the psychoactive mushroom genusProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Article
  19. Review
  20. DNA Authentication and Chemical Analysis ofApplied and environmental microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sebastian DörnerDepartment Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität, Beutenbergstrasse 11a, 07745, Jena, Germany.
Kai RoggeDepartment Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität, Beutenbergstrasse 11a, 07745, Jena, Germany.
Janis FrickeDepartment Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität, Beutenbergstrasse 11a, 07745, Jena, Germany.ORCID 0000-0002-6443-3185
Tim SchäferDepartment Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität, Beutenbergstrasse 11a, 07745, Jena, Germany.
Jacob M WurlitzerDepartment Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität, Beutenbergstrasse 11a, 07745, Jena, Germany.
Markus GresslerDepartment Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität, Beutenbergstrasse 11a, 07745, Jena, Germany.ORCID 0000-0001-5669-7618
Duyen N K PhamDepartment of Chemistry & Biochemistry, University of Massachusetts, 285 Old Westport Road, Dartmouth, MA, 02747, USA.
David R MankeDepartment of Chemistry & Biochemistry, University of Massachusetts, 285 Old Westport Road, Dartmouth, MA, 02747, USA.
Andrew R ChadeayneCaaMTech, LLC, 58 East Sunset Way, Issaquah, WA, 98027, USA.
Dirk HoffmeisterDepartment Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität, Beutenbergstrasse 11a, 07745, Jena, Germany.ORCID 0000-0002-5302-6461
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEUniversity of Massachusetts Dartmouth · USSunset Laboratory (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psilocybe magic mushrooms are best known for their main natural product, psilocybin, and its dephosphorylated congener, the psychedelic metabolite psilocin. Beyond tryptamines, the secondary metabolome of these fungi is poorly understood. The genomes of five species (P. azurescens, P. cubensis, P. cyanescens, P. mexicana, and P. serbica) were browsed to understand more profoundly common and species-specific metabolic capacities. The genomic analyses revealed a much greater and yet unexplored metabolic diversity than evident from parallel chemical analyses. P. cyanescens and P. mexicana were identified as aeruginascin producers. Lumichrome and verpacamide A were also detected as Psilocybe metabolites. The observations concerning the potential secondary metabolome of this fungal genus support pharmacological and toxicological efforts to find a rational basis for yet elusive phenomena, such as paralytic effects, attributed to consumption of some magic mushrooms.

Indexed as

Biological ProductsHallucinogensPsilocybeBiological ProductsHallucinogensaeruginascinkinasesmetabolomepsilocybinsecondary metabolism

Identifiers

PMID35583969
PMCPMC9400892
OpenAlexW4280616839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.