Evidence map›Paper›PMID 35583885›Full record

ArticleTranslational vision science & technology2022

Dynamic Pressure Measurements During Vitrectomy in a Model of the Eye.

Irene Nepita, Alessandro Stocchino, Andrea Dodero, Maila Castellano, Mariantonia Ferrara, Mario R Romano, Rodolfo Repetto

Abstract read
In one paragraph

Article in Translational vision science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Intraocular Pressure Control in Vitreoretinal Surgical Systems.Clinical ophthalmology (Auckland, N.Z.) · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Irene NepitaNanoscopy and NIC@IIT, Istituto Italiano di Tecnologia, Genoa, Italy.
Alessandro StocchinoDepartment of Civil and Environmental Engineering, Hong Kong Polytechnic University, Hong Kong.
Andrea DoderoAdolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland.
Maila CastellanoDepartment of Chemistry and Industrial Chemistry, University of Genoa, Genoa, Italy.
Mariantonia FerraraNewcastle Eye Centre, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Mario R RomanoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy.
Rodolfo RepettoDepartment of Civil, Chemical and Environmental Engineering, University of Genoa, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To accurately evaluate pressure changes during vitrectomy in a rigid model of the vitreous chamber and to test the efficiency of the EVA phacovitrectomy system (Dutch Ophthalmic Research Center) in terms of compensation of intraocular pressure variations. Methods: We tested 23-, 25-, and 27-gauge double-blade vitreous cutters in both vented global pressure control and automatic infusion compensation (AIC) modes in a vitreous chamber model, mimicking the real surgical procedure. Balanced salt solution and artificial vitreous, similar to the real vitreous body, were used. We tested both standard-flow (SF) and high-flow (HF) infusion systems, varying the infusion pressure between 20 and 40 mm Hg. In each experiment, flow rate was also measured. Results: Pressure drop was rapidly and efficiently compensated when 23- and 25-gauge cutters were used in AIC mode, with infusion pressures ranging between 30 and 55 mm Hg. The 27-gauge cutter was less efficient in compensating pressure variations. Pressure fluctuations related to the high-frequency motion of the cutter blade were small compared to the overall pressure variations. The use of the HF infusion system resulted in larger flow rates and lower pressure changes compared to the SF infusion system. Conclusions: Despite the rigid material of the model, the present pressure measurements are in line with previous studies performed on porcine eye. The use of AIC mode compensates intraoperative pressure drops efficiently, with both 23- and 25-gauge cutters. The HF infusion system is more efficient than the SF infusion system. Translational Relevance: The AIC infusion mode efficiently compensates intraoperative pressure drops, in both 23- and 25-gauge experimental vitrectomy. The HF infusion system resulted in larger flow rate and lower pressure changes.

Indexed as

Eye DiseasesVitrectomyAnimalsMicrosurgerySwineTonometry, OcularVitreous Body

Identifiers

PMID35583885
PMCPMC9123487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.