Evidence map›Paper›PMID 35583847›Full record

ReviewEndocrine2022

Adrenal crises in adolescents and young adults.

R Louise Rushworth, Georgina L Chrisp, Suzannah Bownes, David J Torpy, Henrik Falhammar

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. [Transition in cases of complex endocrine and diabetic diseases].Innere Medizin (Heidelberg, Germany) · 2025
    Review
  4. Review
  5. Addison's Disease: Diagnosis and Management Strategies.International journal of general medicine · 2023
    Review
  6. Article
  7. Long-Term Outcomes of Congenital Adrenal Hyperplasia.Endocrinology and metabolism (Seoul, Korea) · 2022
    Review
  8. Article
  9. Circulatory shock in adults in emergency department.Turkish journal of emergency medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

R Louise RushworthSchool of Medicine, Sydney, The University of Notre Dame, 160 Oxford St, Darlinghurst, NSW, 2010, Australia.
Georgina L ChrispSchool of Medicine, Sydney, The University of Notre Dame, 160 Oxford St, Darlinghurst, NSW, 2010, Australia.
Suzannah BownesSchool of Medicine, Sydney, The University of Notre Dame, 160 Oxford St, Darlinghurst, NSW, 2010, Australia.
David J TorpyEndocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
Henrik FalhammarDepartment of Endocrinology, Karolinska University Hospital, SE-17176, Stockholm, Sweden. henrik.falhammar@ki.se.ORCID 0000-0002-5622-6987
The University of Notre Dame Australia · AUKarolinska University Hospital · SERoyal Adelaide Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeReview the literature concerning adrenal insufficiency (AI) and adrenal crisis (AC) in adolescents and young adults.

methodsSearches of PubMed identifying relevant reports up to March 2022.

resultsAI is rare disorder that requires lifelong glucocorticoid replacement therapy and is associated with substantial morbidity and occasional mortality among adolescents and young adults. Aetiologies in this age group are more commonly congenital, with acquired causes, resulting from tumours in the hypothalamic-pituitary area and autoimmune adrenalitis among others, increasing with age. All patients with AI are at risk of AC, which have an estimated incidence of 6 to 8 ACs/100 patient years. Prevention of ACs includes use of educational interventions to achieve competency in dose escalation and parenteral glucocorticoid administration during times of physiological stress, such as an intercurrent infection. While the incidence of AI/AC in young children and adults has been documented, there are few studies focussed on the AC occurrence in adolescents and young adults with AI. This is despite the range of developmental, psychosocial, and structural changes that can interfere with chronic disease management during this important period of growth and development.

conclusionIn this review, we examine the current state of knowledge of AC epidemiology in emerging adults; examine the causes of ACs in this age group; and suggest areas for further investigation that are aimed at reducing the incidence and health impact of ACs in these patients.

Indexed as

Addison DiseaseAdrenal InsufficiencyAcute DiseaseAdolescentChildChild, PreschoolGlucocorticoidsHumansIncidenceYoung AdultGlucocorticoidsAdrenal insufficiencyEmergening adultsIncidenceMortalityPrecipitating factorsPrevention

Identifiers

PMID35583847
PMCPMC9242908
OpenAlexW4280566492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.