Evidence map›Paper›PMID 35583791›Full record

ReviewFolia microbiologica2022

Exploring the multifactorial aspects of Gut Microbiome in Parkinson's Disease.

Sujith Pavan, Arvind N Prabhu, Sankar Prasad Gorthi, Bhabatosh Das, Ankur Mutreja, Vignesh Shetty, Thandavarayan Ramamurthy, Mamatha Ballal

Open access · hybridAbstract readReview
In one paragraph

Review in Folia microbiologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sujith PavanEnteric Diseases Division, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Arvind N PrabhuDepartment of Neurology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Sankar Prasad GorthiDepartment of Neurology, Bharati Vidyapeeth Medical College & Hospital, Pune, India.
Bhabatosh DasMolecular Genetics Laboratory, Centre for Human Microbial Ecology, Translational Health Sciences and Technology Institute, NCR Biotech Science Cluster, Faridabad, India.
Ankur MutrejaEnteric Diseases Division, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Vignesh ShettyEnteric Diseases Division, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Thandavarayan RamamurthyNational Institute of Cholera and Enteric Diseases, Kolkata, India.
Mamatha BallalEnteric Diseases Division, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. mamatha.ballal@manipal.edu.ORCID http://orcid.org/0000-0001-8781-3191
Manipal Academy of Higher Education · INBharati Vidyapeeth Deemed University · INNational Institute of Cholera and Enteric Diseases · INTranslational Health Science and Technology Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced research in health science has broadened our view in approaching and understanding the pathophysiology of diseases and has also revolutionised diagnosis and treatment. Ever since the establishment of Braak's hypothesis in the propagation of alpha-synuclein from the distant olfactory and enteric nervous system towards the brain in Parkinson's Disease (PD), studies have explored and revealed the involvement of altered gut microbiota in PD. This review recapitulates the gut microbiome associated with PD severity, duration, motor and non-motor symptoms, and antiparkinsonian treatment from recent literature. Gut microbial signatures in PD are potential predictors of the disease and are speculated to be used in early diagnosis and treatment. In brief, the review also emphasises on implications of the prebiotic, probiotic, faecal microbiota transplantation, and dietary interventions as alternative treatments in modulating the disease symptoms in PD.

Indexed as

Gastrointestinal MicrobiomeParkinson Diseasealpha-SynucleinAntiparkinson AgentsBrainHumansalpha-SynucleinAntiparkinson AgentsGut-Brain AxisGut dysbiosisMicrobial MetabolitesMicrobiomeParkinson’s Disease

Identifiers

PMID35583791
PMCPMC9526693
OpenAlexW4280528089

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.